3v0a: Difference between revisions
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==2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA== | ==2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA== | ||
<StructureSection load='3v0a' size='340' side='right' caption='[[3v0a]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='3v0a' size='340' side='right'caption='[[3v0a]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3v0a]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3v0a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V0A FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.703Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v0a OCA], [https://pdbe.org/3v0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v0a RCSB], [https://www.ebi.ac.uk/pdbsum/3v0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v0a ProSAT]</span></td></tr> | ||
</table> | |||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/BXAN_CLOBO BXAN_CLOBO] Assembles with botulinum neurotoxin type A (BoNT/A) and protects it against pH-mediated inactivation or protease activity at pH 2.6 (the pH of the animal gastrointestinal tract) but not at pH 6.0 (PubMed:22363010). Necessary for neurotoxicity.<ref>PMID:22363010</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.,Gu S, Rumpel S, Zhou J, Strotmeier J, Bigalke H, Perry K, Shoemaker CB, Rummel A, Jin R Science. 2012 Feb 24;335(6071):977-81. PMID:22363010<ref>PMID:22363010</ref> | Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.,Gu S, Rumpel S, Zhou J, Strotmeier J, Bigalke H, Perry K, Shoemaker CB, Rummel A, Jin R Science. 2012 Feb 24;335(6071):977-81. PMID:22363010<ref>PMID:22363010</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3v0a" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Antibody|Antibody]] | *[[Antibody 3D structures|Antibody 3D structures]] | ||
*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]] | |||
*[[3D structures of non-human antibody|3D structures of non-human antibody]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 25: | Line 30: | ||
[[Category: Clostridium botulinum]] | [[Category: Clostridium botulinum]] | ||
[[Category: Lama glama]] | [[Category: Lama glama]] | ||
[[Category: Bigalke | [[Category: Large Structures]] | ||
[[Category: Gu | [[Category: Bigalke H]] | ||
[[Category: Jin | [[Category: Gu S]] | ||
[[Category: Perry | [[Category: Jin R]] | ||
[[Category: Rummel | [[Category: Perry K]] | ||
[[Category: Rumpel | [[Category: Rummel A]] | ||
[[Category: Shoemaker | [[Category: Rumpel S]] | ||
[[Category: Strotmeier | [[Category: Shoemaker CB]] | ||
[[Category: Zhou | [[Category: Strotmeier J]] | ||
[[Category: Zhou J]] | |||
Latest revision as of 10:32, 6 November 2024
2.7 angstrom crystal structure of BoNT/Ai in complex with NTNHA
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