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{{STRUCTURE_4js8|  PDB=4js8  |  SCENE=  }}
===Crystal structure of TTK kinase domain with an inhibitor: 401348===


==Function==
==Crystal structure of TTK kinase domain with an inhibitor: 401348==
[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
<StructureSection load='4js8' size='340' side='right'caption='[[4js8]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4js8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JS8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PF:4-(CYCLOHEXYLMETHOXY)-3-{4-[(1-METHYLPIPERIDIN-4-YL)OXY]PHENYL}-2H-INDAZOLE'>1PF</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4js8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4js8 OCA], [https://pdbe.org/4js8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4js8 RCSB], [https://www.ebi.ac.uk/pdbsum/4js8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4js8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>  


==About this Structure==
==See Also==
[[4js8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JS8 OCA].
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
 
== References ==
==Reference==
<references/>
<references group="xtra"/><references/>
__TOC__
[[Category: Dual-specificity kinase]]
</StructureSection>
[[Category: Awrey, D E.]]
[[Category: Homo sapiens]]
[[Category: Chirgadze, N Y.]]
[[Category: Large Structures]]
[[Category: Feher, M.]]
[[Category: Awrey DE]]
[[Category: Plotnikov, A N.]]
[[Category: Chirgadze NY]]
[[Category: Plotnikova, O.]]
[[Category: Feher M]]
[[Category: Qiu, W.]]
[[Category: Plotnikov AN]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Plotnikova O]]
[[Category: Qiu W]]
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