8dc5: Difference between revisions
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<StructureSection load='8dc5' size='340' side='right'caption='[[8dc5]], [[Resolution|resolution]] 3.21Å' scene=''> | <StructureSection load='8dc5' size='340' side='right'caption='[[8dc5]], [[Resolution|resolution]] 3.21Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8dc5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[8dc5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthonairovirus_haemorrhagiae Orthonairovirus haemorrhagiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DC5 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.21Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dc5 OCA], [https://pdbe.org/8dc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dc5 RCSB], [https://www.ebi.ac.uk/pdbsum/8dc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dc5 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dc5 OCA], [https://pdbe.org/8dc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dc5 RCSB], [https://www.ebi.ac.uk/pdbsum/8dc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dc5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/A0A7T6Y557_9VIRU A0A7T6Y557_9VIRU] | [https://www.uniprot.org/uniprot/A0A7T6Y557_9VIRU A0A7T6Y557_9VIRU] Binds to host cell surface receptor LDLR and mediates fusion between viral and cellular membranes. Attachment to receptor induces virion internalization predominantly through clathrin-dependent endocytosis. Class II fusion protein that promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Exposure of the glycoprotein spikes to potassium is necessary for the conformational change leading to fusion.[PIRNR:PIRNR003962] Plays a role in virion attachment to host receptor. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Glycoprotein N probably locks the Gn-Gc complex in a prefusion state.[PIRNR:PIRNR003962] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 8dc5" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 8dc5" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Gp41 3D Structures|Gp41 3D Structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Orthonairovirus haemorrhagiae]] | |||
[[Category: Bergeron E]] | [[Category: Bergeron E]] | ||
[[Category: Durie IA]] | [[Category: Durie IA]] | ||
[[Category: McGuire J]] | [[Category: McGuire J]] | ||
[[Category: Pegan SD]] | [[Category: Pegan SD]] | ||
