8ebk: Difference between revisions
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New page: '''Unreleased structure''' The entry 8ebk is ON HOLD Authors: Seo, H.-S., Dhe-Paganon, S. Description: Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC an... |
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==Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC analog== | |||
<StructureSection load='8ebk' size='340' side='right'caption='[[8ebk]], [[Resolution|resolution]] 1.29Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8ebk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EBK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.29Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0EH:(2R)-2-AMINO-2-METHYLNONANOIC+ACID'>0EH</scene>, <scene name='pdbligand=3V3:1-AMINO-3,6,9,12-TETRAOXAPENTADECAN-15-OIC+ACID'>3V3</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=WG0:2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoic+acid'>WG0</scene></td></tr> | ||
[[Category: Dhe-Paganon | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ebk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ebk OCA], [https://pdbe.org/8ebk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ebk RCSB], [https://www.ebi.ac.uk/pdbsum/8ebk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ebk ProSAT]</span></td></tr> | ||
[[Category: Seo | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/MDM4_DANRE MDM4_DANRE] Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Danio rerio]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Dhe-Paganon S]] | |||
[[Category: Seo H-S]] | |||
Latest revision as of 14:31, 6 November 2024
Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC analog
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