1mk9: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[1mk9]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chick Chick~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MK9 OCA]. For a guided tour on the structure components use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1MK9 FirstGlance].

<table><tr><td colspan='2'>[[1mk9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MK9 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=1MK9 FirstGlance].

</td></tr><tr id='~~related~~'><td class="sblockLbl">[[~~Related_structure~~|~~Related~~:]]</td><td class="sblockDat">~~[[1mix|1mix]]~~, [[~~1miz~~|~~1miz]], [[1mk7|1mk7~~]]</td></tr>

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=1mk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mk9 OCA], [~~http~~://pdbe.org/1mk9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=1mk9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/1mk9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=1mk9 ProSAT]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=1mk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mk9 OCA], [https://pdbe.org/1mk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mk9 RCSB], [https://www.ebi.ac.uk/pdbsum/1mk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mk9 ProSAT]</td></tr>

</table>

~~== Disease ==~~

[[http://www.uniprot.org/uniprot/ITB3_HUMAN ITB3_HUMAN]] Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:[http://omim.org/entry/273800 273800]]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.<ref>PMID:2392682</ref> <ref>PMID:1371279</ref> <ref>PMID:1602006</ref> <ref>PMID:1438206</ref> <ref>PMID:8781422</ref> <ref>PMID:9376589</ref> <ref>PMID:9215749</ref> <ref>PMID:9790984</ref> <ref>PMID:9684783</ref> <ref>PMID:10233432</ref> <ref>PMID:11588040</ref> <ref>PMID:11897046</ref> <ref>PMID:12083483</ref> <ref>PMID:12353082</ref> <ref>PMID:15583747</ref> <ref>PMID:15634267</ref> <ref>PMID:15748237</ref>

~~== Function ==~~

[[http://www.uniprot.org/uniprot/ITB3_HUMAN ITB3_HUMAN]] Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [[http://www.uniprot.org/uniprot/TLN1_CHICK TLN1_CHICK]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. Talin is a high molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mk/1mk9_consurf.spt"</scriptWhenChecked>

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>

<text>to colour the structure by Evolutionary Conservation</text>

</jmolCheckbox>

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==See Also==

*[[Talin|Talin]]

*[[Talin 3D structures|Talin 3D structures]]

== References ==

__TOC__

</StructureSection>

[[Category: ~~Chick~~]]

[[Category: Gallus gallus]]

[[Category: ~~Human~~]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Calderwood~~, D A~~]]

[[Category: Calderwood DA]]

[[Category: Campbell~~, I D~~]]

[[Category: Campbell ID]]

[[Category: Critchley, D]]

[[Category: Critchley D]]

[[Category: ~~Garcia-Alvarez, B~~]]

[[Category: De Pereda JM]]

[[Category: ~~Ginsberg, M H~~]]

[[Category: Garcia-Alvarez B]]

[[Category: ~~Liddington, R C~~]]

[[Category: Ginsberg MH]]

[[Category: ~~Pereda, J M.De~~]]

[[Category: Liddington RC]]

[[Category: Ulmer~~, T S]]~~

[[Category: Ulmer TS]]

~~[[Category: Cytoskeleton npxy motif]]~~

~~[[Category: Ferm domain]]~~

~~[[Category: Focal adhesion]]~~

~~[[Category: Integrin binding]]~~

~~[[Category: Ptb domain]]~~

~~[[Category: Structural protein~~]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='1mk9' size='340' side='right'caption='[[1mk9]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1mk9]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MK9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1mk9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MK9 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mix|1mix]], [[1miz|1miz]], [[1mk7|1mk7]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mk9 OCA], [http://pdbe.org/1mk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1mk9 RCSB], [http://www.ebi.ac.uk/pdbsum/1mk9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1mk9 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mk9 OCA], [https://pdbe.org/1mk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mk9 RCSB], [https://www.ebi.ac.uk/pdbsum/1mk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mk9 ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[[http://www.uniprot.org/uniprot/ITB3_HUMAN ITB3_HUMAN]] Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:[http://omim.org/entry/273800 273800]]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.<ref>PMID:2392682</ref> <ref>PMID:1371279</ref> <ref>PMID:1602006</ref> <ref>PMID:1438206</ref> <ref>PMID:8781422</ref> <ref>PMID:9376589</ref> <ref>PMID:9215749</ref> <ref>PMID:9790984</ref> <ref>PMID:9684783</ref> <ref>PMID:10233432</ref> <ref>PMID:11588040</ref> <ref>PMID:11897046</ref> <ref>PMID:12083483</ref> <ref>PMID:12353082</ref> <ref>PMID:15583747</ref> <ref>PMID:15634267</ref> <ref>PMID:15748237</ref>
-== Function ==
-[[http://www.uniprot.org/uniprot/ITB3_HUMAN ITB3_HUMAN]] Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [[http://www.uniprot.org/uniprot/TLN1_CHICK TLN1_CHICK]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. Talin is a high molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 16: / Line 12: @@
    <jmolCheckbox>
      <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mk/1mk9_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 32: / Line 28: @@
 ==See Also==
-*[[Talin|Talin]]
+*[[Talin 3D structures|Talin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Chick]]
+[[Category: Gallus gallus]]
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Calderwood, D A]]
+[[Category: Calderwood DA]]
-[[Category: Campbell, I D]]
+[[Category: Campbell ID]]
-[[Category: Critchley, D]]
+[[Category: Critchley D]]
-[[Category: Garcia-Alvarez, B]]
+[[Category: De Pereda JM]]
-[[Category: Ginsberg, M H]]
+[[Category: Garcia-Alvarez B]]
-[[Category: Liddington, R C]]
+[[Category: Ginsberg MH]]
-[[Category: Pereda, J M.De]]
+[[Category: Liddington RC]]
-[[Category: Ulmer, T S]]
+[[Category: Ulmer TS]]
-[[Category: Cytoskeleton npxy motif]]
-[[Category: Ferm domain]]
-[[Category: Focal adhesion]]
-[[Category: Integrin binding]]
-[[Category: Ptb domain]]
-[[Category: Structural protein]]