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{{STRUCTURE_2e68|  PDB=2e68  |  SCENE=  }}
===Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate===


==Function==
==Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate==
[[http://www.uniprot.org/uniprot/Q4D3W2_TRYCR Q4D3W2_TRYCR]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.  
<StructureSection load='2e68' size='340' side='right'caption='[[2e68]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2e68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E68 FirstGlance]. <br>
[[2e68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E68 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOR:(4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>DOR</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e68 OCA], [https://pdbe.org/2e68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e68 RCSB], [https://www.ebi.ac.uk/pdbsum/2e68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e68 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/2e68_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e68 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Dihydroorotate dehydrogenase|Dihydroorotate dehydrogenase]]
*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:018808149</ref><references group="xtra"/><references/>
[[Category: Large Structures]]
[[Category: Dihydroorotate oxidase]]
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
[[Category: Aoki, T.]]
[[Category: Aoki T]]
[[Category: Harada, S.]]
[[Category: Harada S]]
[[Category: Inaoka, D K.]]
[[Category: Inaoka DK]]
[[Category: Kita, K.]]
[[Category: Kita K]]
[[Category: Kurisu, G.]]
[[Category: Kurisu G]]
[[Category: Nara, T.]]
[[Category: Nara T]]
[[Category: Sakamoto, K.]]
[[Category: Sakamoto K]]
[[Category: Shiba, T.]]
[[Category: Shiba T]]
[[Category: Shimizu, H.]]
[[Category: Shimizu H]]
[[Category: Chagas disease]]
[[Category: Dihydroorotate dehydrogenase]]
[[Category: Energy metabolism]]
[[Category: Flavoprotein]]
[[Category: Fumarate reductase]]
[[Category: Oxidoreductase]]
[[Category: Pyrimidine biosynthesis]]
[[Category: Redox homeostasis]]
Retrieved from "https://proteopedia.org/2e68"