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==Solution structure of a complex consisting of hDlg/SAP-97 residues 318-406 and HPV51 oncoprotein E6 residues 141-151==
==Solution structure of a complex consisting of hDlg/SAP-97 residues 318-406 and HPV51 oncoprotein E6 residues 141-151==
<StructureSection load='2m3m' size='340' side='right' caption='[[2m3m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2m3m' size='340' side='right'caption='[[2m3m]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2m3m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_papillomavirus_type_51 Human papillomavirus type 51]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M3M FirstGlance]. <br>
<table><tr><td colspan='2'>[[2m3m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_papillomavirus_51 Human papillomavirus 51]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M3M FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2m3l|2m3l]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DLG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), E6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10595 Human papillomavirus type 51])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m3m OCA], [https://pdbe.org/2m3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m3m RCSB], [https://www.ebi.ac.uk/pdbsum/2m3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m3m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m3m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m3m RCSB], [http://www.ebi.ac.uk/pdbsum/2m3m PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DLG1_HUMAN DLG1_HUMAN]] Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.<ref>PMID:10656683</ref> <ref>PMID:12445884</ref> <ref>PMID:14699157</ref> <ref>PMID:15263016</ref> <ref>PMID:19213956</ref> <ref>PMID:20605917</ref> [[http://www.uniprot.org/uniprot/VE6_HPV51 VE6_HPV51]] Transcriptional transactivator. Binds double stranded DNA (By similarity).
[https://www.uniprot.org/uniprot/DLG1_HUMAN DLG1_HUMAN] Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.<ref>PMID:10656683</ref> <ref>PMID:12445884</ref> <ref>PMID:14699157</ref> <ref>PMID:15263016</ref> <ref>PMID:19213956</ref> <ref>PMID:20605917</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2m3m" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human papillomavirus type 51]]
[[Category: Human papillomavirus 51]]
[[Category: Gorlach, M]]
[[Category: Large Structures]]
[[Category: Mischo, A]]
[[Category: Gorlach M]]
[[Category: Ohlenschlager, O]]
[[Category: Mischo A]]
[[Category: Dlg]]
[[Category: Ohlenschlager O]]
[[Category: E6]]
[[Category: Hdlg]]
[[Category: Hdlg1]]
[[Category: Hdlgpdz2]]
[[Category: Hpv]]
[[Category: Oncogene protein]]
[[Category: Oncoprotein - cell adhesion protein complex]]
[[Category: Oncoprotein e6]]
[[Category: Oncoprotein-cell adhesion complex]]
[[Category: Papillomavirus e6 protein]]
[[Category: Pdz domain]]
[[Category: Sap-97]]
[[Category: Viral]]
Retrieved from "https://proteopedia.org/2m3m"