3cam: Difference between revisions

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[[Image:3cam.jpg|left|200px]]


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==Crystal structure of the cold shock domain protein from Neisseria meningitidis==
The line below this paragraph, containing "STRUCTURE_3cam", creates the "Structure Box" on the page.
<StructureSection load='3cam' size='340' side='right'caption='[[3cam]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3cam]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_MC58 Neisseria meningitidis MC58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CAM FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
{{STRUCTURE_3cam| PDB=3cam  | SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cam OCA], [https://pdbe.org/3cam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cam RCSB], [https://www.ebi.ac.uk/pdbsum/3cam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cam ProSAT]</span></td></tr>
 
</table>
'''Crystal structure of the cold shock domain protein from Neisseria meningitidis'''
== Function ==
 
[https://www.uniprot.org/uniprot/Q9JZZ4_NEIMB Q9JZZ4_NEIMB]
 
== Evolutionary Conservation ==
==Overview==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/3cam_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cam ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of the cold-shock domain protein from Neisseria meningitidis has been solved to 2.6 A resolution and shown to comprise a dimer formed by the exchange of two beta-strands between protein monomers. The overall fold of the monomer closely resembles those of other bacterial cold-shock proteins. The neisserial protein behaved as a monomer in solution and was shown to bind to a hexathymidine oligonucleotide with a stoichiometry of 1:1 and a K(d) of 1.25 microM.
The structure of the cold-shock domain protein from Neisseria meningitidis has been solved to 2.6 A resolution and shown to comprise a dimer formed by the exchange of two beta-strands between protein monomers. The overall fold of the monomer closely resembles those of other bacterial cold-shock proteins. The neisserial protein behaved as a monomer in solution and was shown to bind to a hexathymidine oligonucleotide with a stoichiometry of 1:1 and a K(d) of 1.25 microM.


==About this Structure==
Structure of the cold-shock domain protein from Neisseria meningitidis reveals a strand-exchanged dimer.,Ren J, Nettleship JE, Sainsbury S, Saunders NJ, Owens RJ Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Apr 1;64(Pt, 4):247-51. Epub 2008 Mar 21. PMID:18391418<ref>PMID:18391418</ref>
3CAM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_mc58 Neisseria meningitidis mc58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CAM OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Structure of the cold-shock domain protein from Neisseria meningitidis reveals a strand-exchanged dimer., Ren J, Nettleship JE, Sainsbury S, Saunders NJ, Owens RJ, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Apr 1;64(Pt, 4):247-51. Epub 2008 Mar 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18391418 18391418]
</div>
[[Category: Neisseria meningitidis mc58]]
<div class="pdbe-citations 3cam" style="background-color:#fffaf0;"></div>
[[Category: Single protein]]
== References ==
[[Category: OPPF, Oxford Protein Production Facility.]]
<references/>
[[Category: Owens, R J.]]
__TOC__
[[Category: Ren, J.]]
</StructureSection>
[[Category: Sainsbury, S.]]
[[Category: Large Structures]]
[[Category: Chain swap]]
[[Category: Neisseria meningitidis MC58]]
[[Category: Cold shock protein]]
[[Category: Owens RJ]]
[[Category: Cytoplasm]]
[[Category: Ren J]]
[[Category: Gene regulation]]
[[Category: Sainsbury S]]
[[Category: Neisseria meningitidi]]
[[Category: Oppf]]
[[Category: Oxford protein production facility]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May  7 09:00:01 2008''
Retrieved from "https://proteopedia.org/3cam"