3s37: Difference between revisions

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New page: '''Unreleased structure''' The entry 3s37 is ON HOLD Authors: Franklin, M.C. Description: Structural basis for the function of two anti-VEGF receptor antibodies
 
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'''Unreleased structure'''


The entry 3s37 is ON HOLD
==Structural basis for the function of two anti-VEGF receptor antibodies==
<StructureSection load='3s37' size='340' side='right'caption='[[3s37]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3s37]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S37 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s37 OCA], [https://pdbe.org/3s37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s37 RCSB], [https://www.ebi.ac.uk/pdbsum/3s37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s37 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The anti-VEGF receptor 2 antibody IMC-1121B is a promising antiangiogenic drug being tested for treatment of breast and gastric cancer. We have determined the structure of the 1121B Fab fragment in complex with domain 3 of VEGFR2, as well as the structure of a different neutralizing anti-VEGFR2 antibody, 6.64, also in complex with VEGFR2 domain 3. The two Fab fragments bind at opposite ends of VEGFR2 domain 3; 1121B directly blocks VEGF binding, whereas 6.64 may prevent receptor dimerization by perturbing the domain 3:domain 4 interface. Mutagenesis reveals that residues essential for VEGF, 1121B, and 6.64 binding are nonoverlapping among the three contact patches.


Authors: Franklin, M.C.
The Structural Basis for the Function of Two Anti-VEGF Receptor 2 Antibodies.,Franklin MC, Navarro EC, Wang Y, Patel S, Singh P, Zhang Y, Persaud K, Bari A, Griffith H, Shen L, Balderes P, Kussie P Structure. 2011 Aug 10;19(8):1097-107. PMID:21827946<ref>PMID:21827946</ref>


Description: Structural basis for the function of two anti-VEGF receptor antibodies
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3s37" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[3D structures of vascular endothelial growth factor receptor|3D structures of vascular endothelial growth factor receptor]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Franklin MC]]
Retrieved from "https://proteopedia.org/3s37"