4f2a: Difference between revisions

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==Crystal structure of cholestryl esters transfer protein in complex with inhibitors==
==Crystal structure of cholestryl esters transfer protein in complex with inhibitors==
<StructureSection load='4f2a' size='340' side='right' caption='[[4f2a]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
<StructureSection load='4f2a' size='340' side='right'caption='[[4f2a]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4f2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F2A FirstGlance]. <br>
<table><tr><td colspan='2'>[[4f2a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F2A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0SF:(2R)-3-{[4-(4-CHLORO-3-ETHYLPHENOXY)PYRIMIDIN-2-YL][3-(1,1,2,2-TETRAFLUOROETHOXY)BENZYL]AMINO}-1,1,1-TRIFLUOROPROPAN-2-OL'>0SF</scene>, <scene name='pdbligand=2OB:CHOLESTERYL+OLEATE'>2OB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.11&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ews|4ews]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0SF:(2R)-3-{[4-(4-CHLORO-3-ETHYLPHENOXY)PYRIMIDIN-2-YL][3-(1,1,2,2-TETRAFLUOROETHOXY)BENZYL]AMINO}-1,1,1-TRIFLUOROPROPAN-2-OL'>0SF</scene>, <scene name='pdbligand=2OB:CHOLESTERYL+OLEATE'>2OB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CETP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2a OCA], [https://pdbe.org/4f2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f2a RCSB], [https://www.ebi.ac.uk/pdbsum/4f2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f2a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4f2a RCSB], [http://www.ebi.ac.uk/pdbsum/4f2a PDBsum]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/CETP_HUMAN CETP_HUMAN]] Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:[http://omim.org/entry/143470 143470]]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).<ref>PMID:2215607</ref> <ref>PMID:8408659</ref> <ref>PMID:12091484</ref>
[https://www.uniprot.org/uniprot/CETP_HUMAN CETP_HUMAN] Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1) [MIM:[https://omim.org/entry/143470 143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).<ref>PMID:2215607</ref> <ref>PMID:8408659</ref> <ref>PMID:12091484</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CETP_HUMAN CETP_HUMAN]] Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.  
[https://www.uniprot.org/uniprot/CETP_HUMAN CETP_HUMAN] Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4f2a" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Liu, S]]
[[Category: Large Structures]]
[[Category: Qiu, X]]
[[Category: Liu S]]
[[Category: Cholestryl ester transfer protein]]
[[Category: Qiu X]]
[[Category: Cholestryl ester transfer protein-inhibitor complex]]
[[Category: High-density lipoprotein]]
[[Category: Lipid transport-inhibitor complex]]
[[Category: Low-density lipoprotein]]
Retrieved from "https://proteopedia.org/4f2a"