4km6: Difference between revisions

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==Human folate receptor alpha (FOLR1) at acidic pH, orthorhombic form==
==Human folate receptor alpha (FOLR1) at acidic pH, orthorhombic form==
<StructureSection load='4km6' size='340' side='right' caption='[[4km6]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='4km6' size='340' side='right'caption='[[4km6]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4km6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KM6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4km6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KM6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4km7|4km7]], [[4kmx|4kmx]], [[4kmy|4kmy]], [[4kmz|4kmz]], [[4kn0|4kn0]], [[4kn1|4kn1]], [[4kn2|4kn2]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FOLR, FOLR1, FOLR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4km6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4km6 OCA], [https://pdbe.org/4km6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4km6 RCSB], [https://www.ebi.ac.uk/pdbsum/4km6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4km6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4km6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4km6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4km6 RCSB], [http://www.ebi.ac.uk/pdbsum/4km6 PDBsum]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:[http://omim.org/entry/613068 613068]]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:[https://omim.org/entry/613068 613068]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.  
[https://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4km6" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: III, C E.Dann]]
[[Category: Large Structures]]
[[Category: Singh, M]]
[[Category: Dann III CE]]
[[Category: 5-methyltetrahydrofolate]]
[[Category: Singh M]]
[[Category: Antifolate]]
[[Category: Folate receptor]]
[[Category: Folate receptor alpha]]
[[Category: Folate-conjugate]]
[[Category: Folate]]
[[Category: Folic acid]]
[[Category: Folr1]]
[[Category: Gpi-anchored protein on eukaryotic membrane]]
[[Category: Membrane protein]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/4km6"