2k4r: Difference between revisions

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{{Seed}}
[[Image:2k4r.jpg|left|200px]]


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==NMR solution structure of the neurotrypsin kringle domain==
The line below this paragraph, containing "STRUCTURE_2k4r", creates the "Structure Box" on the page.
<StructureSection load='2k4r' size='340' side='right'caption='[[2k4r]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2k4r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K4R FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 29 models</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k4r OCA], [https://pdbe.org/2k4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k4r RCSB], [https://www.ebi.ac.uk/pdbsum/2k4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k4r ProSAT]</span></td></tr>
{{STRUCTURE_2k4r|  PDB=2k4r  |  SCENE=  }}
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k4/2k4r_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k4r ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Neurotrypsin is a multidomain protein that serves as a brain-specific serine protease. Here we report the NMR structure of its kringle domain, NT/K. The data analysis was performed with the BACUS (Bayesian analysis of coupled unassigned spins) algorithm. This study presents the first application of BACUS to the structure determination of a (13)C unenriched protein for which no prior experimental 3D structure was available. NT/K adopts the kringle fold, consisting of an antiparallel beta-sheet bridged by an overlapping pair of disulfides. The structure reveals the presence of a surface-exposed left-handed polyproline II helix that is closely packed to the core beta-structure. This feature distinguishes NT/K from other members of the kringle fold and points toward a novel functional role for a kringle domain. Functional divergence among kringle domains is discussed on the basis of their surface and electrostatic characteristics.


===NMR solution structure of the neurotrypsin kringle domain===
NMR Solution Structure of the Neurotrypsin Kringle Domain.,Ozhogina OA, Grishaev A, Bominaar EL, Patthy L, Trexler M, Llinas M Biochemistry. 2008 Oct 29. PMID:18956887<ref>PMID:18956887</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2k4r" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_18956887}}, adds the Publication Abstract to the page
*[[Trypsin 3D structures|Trypsin 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 18956887 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_18956887}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2K4R is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K4R OCA].
 
==Reference==
NMR Solution Structure of the Neurotrypsin Kringle Domain., Ozhogina OA, Grishaev A, Bominaar EL, Patthy L, Trexler M, Llinas M, Biochemistry. 2008 Oct 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18956887 18956887]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Ozhogina, O A.]]
[[Category: Ozhogina OA]]
[[Category: Disulfide-rich protein fold]]
[[Category: Extracellular proteolysis]]
[[Category: Hydrolase]]
[[Category: Kringle domain]]
[[Category: Neurotrypsin]]
[[Category: Serine endopeptidase]]
 
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Retrieved from "https://proteopedia.org/2k4r"