3jwp: Difference between revisions
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New page: '''Unreleased structure''' The entry 3jwp is ON HOLD Authors: Wernimont, A.K., Hutchinson, A., Lin, Y.H., MacKenzie, F., Senisterra, G., Allali-Hassanali, A., Vedadi, M., Ravichandran, ... |
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==Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP== | |||
<StructureSection load='3jwp' size='340' side='right'caption='[[3jwp]], [[Resolution|resolution]] 2.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3jwp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JWP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jwp OCA], [https://pdbe.org/3jwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jwp RCSB], [https://www.ebi.ac.uk/pdbsum/3jwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jwp ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SIR2A_PLAF7 SIR2A_PLAF7] NAD-dependent protein deacylase (PubMed:21992006). Catalyzes the NAD-dependent hydrolysis of medium and long chain fatty acyl groups from lysine residues (PubMed:21992006). Has weak NAD-dependent protein deacetylase activity (PubMed:17827348, PubMed:18221799, PubMed:18397290, PubMed:18729382, PubMed:20601220, PubMed:21992006). Regulates the endonuclease activity of ALBA3 by deacetylation of 'Lys-23' (PubMed:22006844, PubMed:36947546). Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis (PubMed:15820676, PubMed:22379140). Cooperates with Sir2B to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance (PubMed:19402747). Involved in recruiting ORC1 to the telomers and subtelomeric repeat regions (TAREs) and promoters of var genes (PubMed:22379140). Can ADP-ribosylate both histones and itself (PubMed:17827348). May also have a role in telomeric end protection (PubMed:18525026).<ref>PMID:15820676</ref> <ref>PMID:17827348</ref> <ref>PMID:18221799</ref> <ref>PMID:18397290</ref> <ref>PMID:18525026</ref> <ref>PMID:18729382</ref> <ref>PMID:19402747</ref> <ref>PMID:20601220</ref> <ref>PMID:21992006</ref> <ref>PMID:22006844</ref> <ref>PMID:22379140</ref> <ref>PMID:36947546</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/3jwp_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jwp ConSurf]. | |||
<div style="clear:both"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Plasmodium falciparum 3D7]] | |||
[[Category: Allali-Hassanali A]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Brand V]] | |||
[[Category: Cossar D]] | |||
[[Category: Edwards AM]] | |||
[[Category: Hui R]] | |||
[[Category: Hutchinson A]] | |||
[[Category: Kozieradzki I]] | |||
[[Category: Lin YH]] | |||
[[Category: MacKenzie F]] | |||
[[Category: Qiu W]] | |||
[[Category: Ravichandran M]] | |||
[[Category: Schapira M]] | |||
[[Category: Senisterra G]] | |||
[[Category: Vedadi M]] | |||
[[Category: Weigelt J]] | |||
[[Category: Wernimont AK]] | |||
[[Category: Zhao Y]] | |||
Latest revision as of 06:22, 27 November 2024
Crystal structure of Plasmodium falciparum SIR2A (PF13_0152) in complex with AMP
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