8vxt: Difference between revisions
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New page: '''Unreleased structure''' The entry 8vxt is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures |
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==Cryo-EM structure of mammalian Thorase filament, 3-layer refinement== | |||
<StructureSection load='8vxt' size='340' side='right'caption='[[8vxt]], [[Resolution|resolution]] 4.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8vxt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VXT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.25Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vxt OCA], [https://pdbe.org/8vxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vxt RCSB], [https://www.ebi.ac.uk/pdbsum/8vxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vxt ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ATAD1_MOUSE ATAD1_MOUSE] Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (By similarity). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (PubMed:21496646). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (PubMed:21496646).[UniProtKB:P28737][UniProtKB:Q8NBU5]<ref>PMID:21496646</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Dar MA]] | |||
[[Category: Dawson TM]] | |||
[[Category: Dawson VL]] | |||
[[Category: Louder RK]] | |||
[[Category: Umanah GK]] | |||
Latest revision as of 19:56, 11 December 2024
Cryo-EM structure of mammalian Thorase filament, 3-layer refinement
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