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[[Image:2ao7.gif|left|200px]]
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{{STRUCTURE_2ao7|  PDB=2ao7  |  SCENE=  }}
'''Adam10 Disintegrin and cysteine- rich domain'''


==Adam10 Disintegrin and cysteine- rich domain==
<StructureSection load='2ao7' size='340' side='right'caption='[[2ao7]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2ao7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AO7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ao7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ao7 OCA], [https://pdbe.org/2ao7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ao7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ao7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ao7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ADA10_BOVIN ADA10_BOVIN] Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling (By similarity).<ref>PMID:10097139</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ao/2ao7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ao7 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease.


==Overview==
ADAM and Eph: how Ephrin-signaling cells become detached.,Mancia F, Shapiro L Cell. 2005 Oct 21;123(2):185-7. PMID:16239135<ref>PMID:16239135</ref>
Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
2AO7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AO7 OCA].
</div>
<div class="pdbe-citations 2ao7" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
ADAM and Eph: how Ephrin-signaling cells become detached., Mancia F, Shapiro L, Cell. 2005 Oct 21;123(2):185-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16239135 16239135]
*[[A Disintegrin And Metalloproteinase|A Disintegrin And Metalloproteinase]]
[[Category: ADAM10 endopeptidase]]
*[[A Disintegrin And Metalloproteinase 3D structures|A Disintegrin And Metalloproteinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Barton, W A.]]
[[Category: Barton WA]]
[[Category: Blobel, C P.]]
[[Category: Blobel CP]]
[[Category: Himanen, J P.]]
[[Category: Himanen J-P]]
[[Category: Janes, P W.]]
[[Category: Janes PW]]
[[Category: Kolev, M V.]]
[[Category: Kolev MV]]
[[Category: Lackmann, M.]]
[[Category: Lackmann M]]
[[Category: Nievergall, E.]]
[[Category: Nievergall E]]
[[Category: Nikolov, D B.]]
[[Category: Nikolov DB]]
[[Category: Saha, N.]]
[[Category: Saha N]]
[[Category: Wimmer-Kleikamp, S H.]]
[[Category: Wimmer-Kleikamp SH]]
[[Category: Disintegrin]]
[[Category: Extracellular]]
[[Category: Protease]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:16:48 2008''
Retrieved from "https://proteopedia.org/2ao7"