HIF1A: Difference between revisions

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~~==Your Heading Here (maybe something like 'Structure')==~~

== Introduction ==

HIF1α is a subunit of the transcription factor HIF1, together with HIF1β <ref name="Neill>O’Neill, Luke A. J., Rigel J. Kishton, and Jeff Rathmell. 2016. “A Guide to Immunometabolism for Immunologists.” Nature Reviews Immunology 16 (9): 553–65. https://doi.org/10.1038/nri.2016.70.

'''HIF1α''' is a subunit of the transcription factor HIF1, together with HIF1β <ref name="Neill>O’Neill, Luke A. J., Rigel J. Kishton, and Jeff Rathmell. 2016. “A Guide to Immunometabolism for Immunologists.” Nature Reviews Immunology 16 (9): 553–65. https://doi.org/10.1038/nri.2016.70.

</ref>. HIF1α is part exclusively of HIF1 whilst HIF1β is part of other transcription factors as well as HIF1.

HIF1 is related to glucose metabolism, stimulation of circulation and it was first described in hypoxia conditions, but it is now known that it can be activated also in normoxia situations, acting especially in the polarization of immune cells to more inflammatory phenotypes <ref name="Neill"</ref>.

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-==Your Heading Here (maybe something like 'Structure')==
+<StructureSection load='1H2K' size='340' side='right' caption='Human hypoxia-inducible factor 1 alpha C-terminal activation domain residues 776-829 (mustard) complex with factor inhibiting HIF1 ( grey, green) complex with sulphate, oxalylglycine and Fe+2 (grey) (PDB code [[1h2k]])' scene=''>
-<StructureSection load='1H2K' size='340' side='right' caption='Caption for this structure' scene=''>
 == Introduction ==
-HIF1α is a subunit of the transcription factor HIF1, together with HIF1β <ref name="Neill>O’Neill, Luke A. J., Rigel J. Kishton, and Jeff Rathmell. 2016. “A Guide to Immunometabolism for Immunologists.” Nature Reviews Immunology 16 (9): 553–65. https://doi.org/10.1038/nri.2016.70.
+'''HIF1α''' is a subunit of the transcription factor HIF1, together with HIF1β <ref name="Neill>O’Neill, Luke A. J., Rigel J. Kishton, and Jeff Rathmell. 2016. “A Guide to Immunometabolism for Immunologists.” Nature Reviews Immunology 16 (9): 553–65. https://doi.org/10.1038/nri.2016.70.
 </ref>. HIF1α is part exclusively of HIF1 whilst HIF1β is part of other transcription factors as well as HIF1.
 HIF1 is related to glucose metabolism, stimulation of circulation and it was first described in hypoxia conditions, but it is now known that it can be activated also in normoxia situations, acting especially in the polarization of immune cells to more inflammatory phenotypes <ref name="Neill"</ref>.