8pkn: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry 8pkn is ON HOLD~~

==CryoEM structure of catalytic domain of human HMG-CoA reductase with its inhibitor atorvastatin==

~~Authors: Manikandan, K., Van Rooyen, J.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[8pkn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PKN OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8PKN FirstGlance].

~~Description:~~ CryoEM structure of catalytic domain of human HMG-CoA reductase with its inhibitor atorvastatin

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.26Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=117:7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-+3,5-DIHYDROXY-HEPTANOIC+ACID'>117</scene></td></tr>

[[Category: Manikandan, K]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8pkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pkn OCA], [https://pdbe.org/8pkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pkn RCSB], [https://www.ebi.ac.uk/pdbsum/8pkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pkn ProSAT]</td></tr>

[[Category: Van Rooyen, J]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/HMDH_HUMAN HMDH_HUMAN] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Manikandan K]]

[[Category: Van Rooyen J]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8pkn is ON HOLD
+==CryoEM structure of catalytic domain of human HMG-CoA reductase with its inhibitor atorvastatin==
+<StructureSection load='8pkn' size='340' side='right'caption='[[8pkn]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
-Authors: Manikandan, K., Van Rooyen, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8pkn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PKN FirstGlance]. <br>
-Description: CryoEM structure of catalytic domain of human HMG-CoA reductase with its inhibitor atorvastatin
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=117:7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-+3,5-DIHYDROXY-HEPTANOIC+ACID'>117</scene></td></tr>
-[[Category: Manikandan, K]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pkn OCA], [https://pdbe.org/8pkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pkn RCSB], [https://www.ebi.ac.uk/pdbsum/8pkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pkn ProSAT]</span></td></tr>
-[[Category: Van Rooyen, J]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HMDH_HUMAN HMDH_HUMAN] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Manikandan K]]
+[[Category: Van Rooyen J]]