1nf7: Difference between revisions

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New page: left|200px<br /> <applet load="1nf7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nf7, resolution 2.65Å" /> '''Ternary complex of ...
 
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[[Image:1nf7.gif|left|200px]]<br />
<applet load="1nf7" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1nf7, resolution 2.65&Aring;" />
'''Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2-Mycophenolic Adenine Dinucleotide'''<br />


==About this Structure==
==Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2-Mycophenolic Adenine Dinucleotide==
1NF7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with K, RVP, MYD and UNK as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NF7 OCA].  
<StructureSection load='1nf7' size='340' side='right'caption='[[1nf7]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1nf7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NF7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MYD:{[5-(6-AMINO-PURIN-7-YL)-3,4-DIHYDROXY-TETRAHYDRO-FURAN-2-YLMETHOXY]-HYDROXY-PHOSPHORYLMETHYL}-PHOSPHONIC+ACID+MONO-[2-(4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-1,3-DIHYDRO-ISOBENZOFURAN-5-YL)-ETHYL]+ESTER'>MYD</scene>, <scene name='pdbligand=RVP:RIBAVIRIN+MONOPHOSPHATE'>RVP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nf7 OCA], [https://pdbe.org/1nf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nf7 RCSB], [https://www.ebi.ac.uk/pdbsum/1nf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nf7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IMDH2_HUMAN IMDH2_HUMAN] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.[HAMAP-Rule:MF_03156]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nf/1nf7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nf7 ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: IMP dehydrogenase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Goldstein BM]]
[[Category: Goldstein, B.M.]]
[[Category: Risal D]]
[[Category: Risal, D.]]
[[Category: Strickler MD]]
[[Category: Strickler, M.D.]]
[[Category: K]]
[[Category: MYD]]
[[Category: RVP]]
[[Category: UNK]]
[[Category: 8 stranded paralle alpha/beta barrel]]
[[Category: c2-mad]]
[[Category: dehydrogenase]]
[[Category: impd]]
[[Category: impdh]]
[[Category: ribavirin monophosphate]]
 
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Retrieved from "https://proteopedia.org/1nf7"