8rc5: Difference between revisions

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New page: '''Unreleased structure''' The entry 8rc5 is ON HOLD Authors: Description: Category: Unreleased Structures
 
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'''Unreleased structure'''


The entry 8rc5 is ON HOLD
==Complex between the RecA-like Sak4 SSAP and the SaPI2 Stl master regulator==
<StructureSection load='8rc5' size='340' side='right'caption='[[8rc5]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8rc5]] is a 36 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] and [https://en.wikipedia.org/wiki/Staphylococcus_phage_52A Staphylococcus phage 52A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RC5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rc5 OCA], [https://pdbe.org/8rc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rc5 RCSB], [https://www.ebi.ac.uk/pdbsum/8rc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rc5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q4ZAS5_9CAUD Q4ZAS5_9CAUD]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bacteria often carry multiple genes encoding anti-phage defense systems, clustered in defense islands and phage satellites. Various unrelated anti-phage defense systems target phage-encoded homologous recombinases (HRs) through unclear mechanisms. Here, we show that the phage satellite SaPI2, which does not encode orthodox anti-phage defense systems, provides antiviral immunity mediated by Stl2, the SaPI2-encoded transcriptional repressor. Stl2 targets and inhibits phage-encoded HRs, including Sak and Sak4, two HRs from the Rad52-like and Rad51-like superfamilies. Remarkably, apo Stl2 forms a collar of dimers oligomerizing as closed rings and as filaments, mimicking the quaternary structure of its targets. Stl2 decorates both Sak rings and Sak4 filaments. The oligomerization of Stl2 as a collar of dimers is necessary for its inhibitory activity both in vitro and in vivo. Our results shed light on the mechanisms underlying antiviral immunity against phages carrying divergent HRs.


Authors:  
Phage parasites targeting phage homologous recombinases provide antiviral immunity.,Debiasi-Anders G, Qiao C, Salim A, Li N, Mir-Sanchis I Nat Commun. 2025 Feb 22;16(1):1889. doi: 10.1038/s41467-025-57156-3. PMID:39987160<ref>PMID:39987160</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 8rc5" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus phage 52A]]
[[Category: Debiasi-Anders G]]
[[Category: Mir-Sanchis I]]
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