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==SOLUTION STRUCTURE OF OMEGA-CONOTOXIN GVIA USING 2-D NMR SPECTROSCOPY AND RELAXATION MATRIX ANALYSIS==
==SOLUTION STRUCTURE OF OMEGA-CONOTOXIN GVIA USING 2-D NMR SPECTROSCOPY AND RELAXATION MATRIX ANALYSIS==
<StructureSection load='1omc' size='340' side='right' caption='[[1omc]], [[NMR_Ensembles_of_Models | 21 NMR models]]' scene=''>
<StructureSection load='1omc' size='340' side='right'caption='[[1omc]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1omc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conge Conge]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OMC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OMC FirstGlance]. <br>
<table><tr><td colspan='2'>[[1omc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_geographus Conus geographus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OMC FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 21 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1omc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1omc OCA], [http://pdbe.org/1omc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1omc RCSB], [http://www.ebi.ac.uk/pdbsum/1omc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1omc ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1omc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1omc OCA], [https://pdbe.org/1omc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1omc RCSB], [https://www.ebi.ac.uk/pdbsum/1omc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1omc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CO16A_CONGE CO16A_CONGE]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).  
[https://www.uniprot.org/uniprot/O16A_CONGE O16A_CONGE] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks N-type calcium channels (Cav2.2/CACNA1B) with a high potency (it displaces [125I]GVIA with an IC(50)=3.7-38 pM) (PubMed:10938268, PubMed:11724570).<ref>PMID:10938268</ref> <ref>PMID:11724570</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Conge]]
[[Category: Conus geographus]]
[[Category: Basus, V J]]
[[Category: Large Structures]]
[[Category: Bradley, E K]]
[[Category: Basus VJ]]
[[Category: Davis, J H]]
[[Category: Bradley EK]]
[[Category: Miljanich, G P]]
[[Category: Davis JH]]
[[Category: Nadasdi, L]]
[[Category: Miljanich GP]]
[[Category: Ramachandran, J]]
[[Category: Nadasdi L]]
[[Category: Presynaptic neurotoxin]]
[[Category: Ramachandran J]]
Retrieved from "https://proteopedia.org/1omc"