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==Solution structure of MrIA==
==Solution structure of MrIA==
<StructureSection load='2ew4' size='340' side='right' caption='[[2ew4]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2ew4' size='340' side='right'caption='[[2ew4]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ew4]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EW4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EW4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ew4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_marmoreus Conus marmoreus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EW4 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ew4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ew4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ew4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ew4 PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ew4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ew4 OCA], [https://pdbe.org/2ew4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ew4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ew4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ew4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CTA1A_CONMR CTA1A_CONMR] Chi-conotoxins inhibit the neuronal noradrenaline transporter (NET/SLC6A2) (PubMed:11528421, PubMed:12837768, PubMed:12885787, PubMed:16154696). Activity has been described on both human (inhibition of norepinephrine uptake is IC(50)=1.26 uM) and rat (pIC(50)=6.21 corresponding IC(50)=0.16 uM) transporters (PubMed:11528421, PubMed:12885787). Acts as a reversible non-competitive inhibitor (PubMed:11528421).<ref>PMID:11528421</ref> <ref>PMID:12837768</ref> <ref>PMID:12885787</ref> <ref>PMID:16154696</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2ew4" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Alewood, P F.]]
[[Category: Conus marmoreus]]
[[Category: Caesar, C E.]]
[[Category: Large Structures]]
[[Category: Craik, D J.]]
[[Category: Alewood PF]]
[[Category: Daly, N L.]]
[[Category: Caesar CE]]
[[Category: Johansson, H M.]]
[[Category: Craik DJ]]
[[Category: Lewis, R J.]]
[[Category: Daly NL]]
[[Category: Lovelace, E S.]]
[[Category: Johansson HM]]
[[Category: Nilsson, K P.]]
[[Category: Lewis RJ]]
[[Category: Sharpe, I A.]]
[[Category: Lovelace ES]]
[[Category: Tynngard, N.]]
[[Category: Nilsson KP]]
[[Category: Beta hairpin]]
[[Category: Sharpe IA]]
[[Category: Gamma turn]]
[[Category: Tynngard N]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/2ew4"