2jax: Difference between revisions

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[[Image:2jax.jpg|left|200px]]


<!--
==Universal Stress Protein Rv2623 from Mycobaterium Tuberculosis==
The line below this paragraph, containing "STRUCTURE_2jax", creates the "Structure Box" on the page.
<StructureSection load='2jax' size='340' side='right'caption='[[2jax]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2jax]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JAX FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.22&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
{{STRUCTURE_2jax|  PDB=2jax |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jax OCA], [https://pdbe.org/2jax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jax RCSB], [https://www.ebi.ac.uk/pdbsum/2jax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jax ProSAT]</span></td></tr>
 
</table>
'''UNIVERSAL STRESS PROTEIN RV2623 FROM MYCOBATERIUM TUBERCULOSIS'''
== Function ==
 
[https://www.uniprot.org/uniprot/Y2623_MYCTU Y2623_MYCTU] May play a role in the establishment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpression of the protein retards growth in culture; Glu-15 and Ala-117 mutant proteins which bind less ATP do not show this retardation, suggesting growth may be regulated through an ATP-dependent function.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2JAX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JAX OCA].  
Check<jmol>
[[Category: Mycobacterium tuberculosis]]
  <jmolCheckbox>
[[Category: Single protein]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/2jax_consurf.spt"</scriptWhenChecked>
[[Category: Bartunik, H D.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Bourenkov, G.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Oberschall, A.]]
  </jmolCheckbox>
[[Category: Strizhov, N.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jax ConSurf].
[[Category: Atp binding]]
<div style="clear:both"></div>
[[Category: Protein binding]]
__TOC__
[[Category: Universal stress protein]]
</StructureSection>
[[Category: Usp]]
[[Category: Large Structures]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:37:38 2008''
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Bartunik HD]]
[[Category: Bourenkov G]]
[[Category: Oberschall A]]
[[Category: Strizhov N]]
Retrieved from "https://proteopedia.org/2jax"