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[[Image:2jis.gif|left|200px]]<br />
<applet load="2jis" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2jis, resolution 1.60&Aring;" />
'''HUMAN CYSTEINE SULFINIC ACID DECARBOXYLASE (CSAD) IN COMPLEX WITH PLP.'''<br />


==About this Structure==
==Human cysteine sulfinic acid decarboxylase (CSAD) in complex with PLP.==
2JIS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NO3 and PLP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Sulfinoalanine_decarboxylase Sulfinoalanine decarboxylase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.29 4.1.1.29]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JIS OCA]].  
<StructureSection load='2jis' size='340' side='right'caption='[[2jis]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2jis]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JIS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jis OCA], [https://pdbe.org/2jis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jis RCSB], [https://www.ebi.ac.uk/pdbsum/2jis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jis ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CSAD_HUMAN CSAD_HUMAN] Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate.[UniProtKB:Q9DBE0]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/2jis_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jis ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Sulfinoalanine decarboxylase]]
[[Category: Arrowsmith C]]
[[Category: Arrowsmith, C.]]
[[Category: Berglund H]]
[[Category: Berg, S.Van.Den.]]
[[Category: Busam R]]
[[Category: Berglund, H.]]
[[Category: Collins R]]
[[Category: Busam, R.]]
[[Category: Dahlgren LG]]
[[Category: Collins, R.]]
[[Category: Edwards A]]
[[Category: Dahlgren, L.G.]]
[[Category: Flodin S]]
[[Category: Edwards, A.]]
[[Category: Flores A]]
[[Category: Flodin, S.]]
[[Category: Graslund S]]
[[Category: Flores, A.]]
[[Category: Hallberg BM]]
[[Category: Graslund, S.]]
[[Category: Hammarstrom M]]
[[Category: Hallberg, B.M.]]
[[Category: Holmberg-Schiavone L]]
[[Category: Hammarstrom, M.]]
[[Category: Johansson I]]
[[Category: Holmberg-Schiavone, L.]]
[[Category: Kallas A]]
[[Category: Johansson, I.]]
[[Category: Karlberg T]]
[[Category: Kallas, A.]]
[[Category: Kotenyova T]]
[[Category: Karlberg, T.]]
[[Category: Lehtio L]]
[[Category: Kotenyova, T.]]
[[Category: Moche M]]
[[Category: Lehtio, L.]]
[[Category: Nordlund P]]
[[Category: Moche, M.]]
[[Category: Nyman T]]
[[Category: Nordlund, P.]]
[[Category: Ogg D]]
[[Category: Nyman, T.]]
[[Category: Persson C]]
[[Category: Ogg, D.]]
[[Category: Sagemark J]]
[[Category: Persson, C.]]
[[Category: Stenmark P]]
[[Category: Sagemark, J.]]
[[Category: Sundstrom M]]
[[Category: Sgc, Structural GenomicsConsortium.]]
[[Category: Thorsell AG]]
[[Category: Stenmark, P.]]
[[Category: Tresaugues L]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Thorsell, A.G.]]
[[Category: Welin M]]
[[Category: Tresaugues, L.]]
[[Category: Van den Berg S]]
[[Category: Weigelt, J.]]
[[Category: Welin, M.]]
[[Category: NO3]]
[[Category: PLP]]
[[Category: alternative splicing]]
[[Category: decarboxylase]]
[[Category: lyase]]
[[Category: pyridoxal phosphate]]
[[Category: pyridoxal phosphate (plp)]]
[[Category: structural genomics consortium (sgc)]]
[[Category: vitamin b6]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:35:13 2007''
Retrieved from "https://proteopedia.org/2jis"