DNA damage-binding protein: Difference between revisions

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[[Image:3ei1.png|left|200px|thumb|Crystal structure of human DDB1 (grey) and DDB2 (green) complex with DNA [[3ei1]]]]
<StructureSection load='3ei1' size='350' side='right' caption='Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code [[3ei1]]).' scene='54/541124/Cv/1'>
{{STRUCTURE_3ei1|  PDB=3ei1 | SIZE=350| SCENE= |right|CAPTION=Human DDB1 (grey) and DDB2 (green) complex with DNA, TMP and tetraethylene glycol [[3ei1]] }}
__TOC__
== Function ==


'''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair.  It prevents UV damage to DNA.  <scene name='54/541124/Cv/2'>DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2</scene>.


DNA in this complex with DDB1 and DDB2 contains modified compounds <scene name='54/541124/Cv/5'>5PY and 64T</scene> (in darkmagenta and magenta, respectively), they are derivatives from parent compound THYMIDINE-5'-MONOPHOSPHATE.<ref>PMID:18593899</ref><br /> Water molecules shown as red spheres.


== Disease ==


 
Defective activity of DDB2 causes the repair defects in patients with XPE - an autosomal disorder characterized by early onset of cancer and photosensitivity.  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
'''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair.  It prevents UV damage to DNA.  DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2.


== 3D Structures of DNA damage-binding protein ==
== 3D Structures of DNA damage-binding protein ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[DNA damage-binding protein 3D structures]]
 
===DDB1===
 
[[2b5l]] – hDDB + simian virus 5 protein – human<br />
[[2b5m]] – hDDB <br />
[[2b5m]], [[2b5n]] – hDDB BPB domain<br />
[[2hye]] – hDDB + simian virus 5 protein + cullin-4A + ring-box protein 1<br />
[[3e0c]] – hDDB <br />
[[3i7h]], [[3i7k]], [[3i7l]], [[3i7n]], [[3i7o]], [[3i7p]], [[3i89]], [[3i8c]], [[3i8e]] – hDDB + X protein peptide<br />
[[4a11]] – hDDB + DNA excision repair protein ERCC-8<br />
 
===DDB1+DDB2===


[[3ei1]], [[3ei2]], [[4a08]], [[4a09]], [[4a0a]], [[4a0b]], [[4e54]], [[4e5z]] – hDDB + DNA<br />
== References ==
[[3ei3]], [[3ei4]] – hDDB <br />
<references/>
[[4a0k]] – hDDB + cullin-4A + ring-box protein 1<br />
</StructureSection>
[[4a0l]] – hDDB + cullin-4A + ring-box protein 1 + DNA<br />
[[Category:Topic Page]]
[[Category:Topic Page]]
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