User:Elizabeth Cook/Sandbox 1: Difference between revisions
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Cpd6 makes contacts to CECR2 through N514 (2 direct H-bonds) and D464 (1 direct H-bond, and 1 H-bond coordinated by water). <ref>PMID:28740608</ref> | Cpd6 makes contacts to CECR2 through N514 (2 direct H-bonds) and D464 (1 direct H-bond, and 1 H-bond coordinated by water). <ref>PMID:28740608</ref> | ||
In efforts to develop new small molecule inhibitors for the CECR2 bromodomain, <scene name='10/1079536/Cpd6/1'>Cpd6</scene>, an acetyllysine mimetic, has been synthesized and studied. The inhibitor is coordinated by the conserved <scene name='10/1079536/N514/1'>N514</scene> in which <scene name='10/1079536/2_bonds/1'>2 direct H-bonds</scene> form. | In efforts to develop new small molecule inhibitors for the CECR2 bromodomain, <scene name='10/1079536/Cpd6/1'>Cpd6</scene>, an acetyllysine mimetic, has been synthesized and studied. The inhibitor is coordinated by the conserved <scene name='10/1079536/N514/1'>N514</scene> in which <scene name='10/1079536/2_bonds/1'>2 direct H-bonds</scene> form, and <scene name='10/1079536/D464/1'>D464</scene> in which there is one direct H-bond and one coordinated through water. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
