Dynactin: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
Michal Harel (talk | contribs)
32,831 edits
No edit summary
Michal Harel (talk | contribs)
32,831 edits
No edit summary
 
(32 intermediate revisions by 2 users not shown)
Line 1: Line 1:
[[Image:2hkq.png|left|200px|thumb|Crystal Structure of Dynactin, [[2hkq]]]]
<StructureSection load='2hl5' size='350' side='right' scene='44/444636/Cv/1' caption='Dynactin subunit 1 CAP-Gly domain (magenta and yellow) complex with the C-terminal domain of human EB1 (cyan and green) and chloride ion [[2hl5]]'>
{{STRUCTURE_2hkq|  PDB=2hkq  | SIZE=300|  |right|CAPTION=Dynactin subunit 1 CAP-Gly domain complex with protein linker, [[2hkq]] }}


'''Dynactin''' (DCTN) is a multi-subunit protein which modulates the binding of dynein to cell organelles which are to be transported along microtubules.
__TOC__


{{TOC limit|limit=2}}
== Function ==


'''Dynactin''' (DCTN) is a multi-subunit protein which modulates the binding of dynein to cell organelles which are to be transported along microtubules.<ref>PMID:1836789</ref> See also [[CAP-Gly domain]].


== Disease ==


Mutant dynactin was found in motor neuron disease.<ref>PMID:12627231</ref>




== Structural highlights ==
<scene name='44/444636/Cv/3'>Dynactin subunit 1 CAP-Gly domain with the C-terminal domain of human EB1</scene> ([[2hl5]]).<ref>PMID:16949363</ref>


== 3D Structures of Dynactin ==
[[Dynactin 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


 
== References ==
 
<references/>
 
</StructureSection>
 
[[Category:Topic Page]]
 
 
== 3D Structures of Dynactin ==
 
[[2coy]] - hDCTN subunit 1 CAP-Gly domain – human – NMR<br />
[[3e2u]] – hDCTN subunit 1 CAP-Gly domain + CAP-Gly domain-containing protein linker 1<br />
[[2hkq]], [[2hl3]], [[1txq]] - hDCTN subunit 1 CAP-Gly domain + microtubule-associated protein C-terminal<br />
[[2hl5]] - hDCTN subunit 1 CAP-Gly domain (mutant) + microtubule-associated protein C-terminal
Retrieved from "https://proteopedia.org/Dynactin"