Dynactin: Difference between revisions

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[[Image:2hkq.png|left|200px|thumb|Crystal Structure of Dynactin (green) complex with protein linker (grey), [[2hkq]]]]
<StructureSection load='2hl5' size='350' side='right' scene='44/444636/Cv/1' caption='Dynactin subunit 1 CAP-Gly domain (magenta and yellow) complex with the C-terminal domain of human EB1 (cyan and green) and chloride ion [[2hl5]]'>
{{STRUCTURE_2hl5|  PDB=2hl5 | SIZE=400| SCENE= |right|CAPTION=Dynactin subunit 1 CAP-Gly domain (pink and yellow) complex with protein linker (grey and green) and chloride ion [[2hl5]] }}
 
'''Dynactin''' (DCTN) is a multi-subunit protein which modulates the binding of dynein to cell organelles which are to be transported along microtubules.
 
{{TOC limit|limit=2}}
 
 
 
 
 
 
 
 


__TOC__


== Function ==


'''Dynactin''' (DCTN) is a multi-subunit protein which modulates the binding of dynein to cell organelles which are to be transported along microtubules.<ref>PMID:1836789</ref> See also [[CAP-Gly domain]].


== Disease ==


Mutant dynactin was found in motor neuron disease.<ref>PMID:12627231</ref>




== Structural highlights ==
<scene name='44/444636/Cv/3'>Dynactin subunit 1 CAP-Gly domain with the C-terminal domain of human EB1</scene> ([[2hl5]]).<ref>PMID:16949363</ref>


== 3D Structures of Dynactin ==
== 3D Structures of Dynactin ==
[[Dynactin 3D structures]]


''Update June 2011''
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
[[2coy]] - hDCTN subunit 1 CAP-Gly domain – human – NMR<br />
[[3e2u]] – hDCTN subunit 1 CAP-Gly domain + CAP-Gly domain-containing protein linker 1<br />
[[2hkq]], [[2hl3]], [[1txq]] - hDCTN subunit 1 CAP-Gly domain + microtubule-associated protein C-terminal<br />
[[2hqh]] - hDCTN subunit 1 CAP-Gly domain + restin 2nd zinc finger domain<br />
[[2hl5]] - hDCTN subunit 1 CAP-Gly domain (mutant) + microtubule-associated protein C-terminal


== References ==
<references/>
</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]
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