8erc: Difference between revisions
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==Human Membrane-bound O-acyltransferase 7== | |||
<StructureSection load='8erc' size='340' side='right'caption='[[8erc]], [[Resolution|resolution]] 3.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8erc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ERC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ERC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8erc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8erc OCA], [https://pdbe.org/8erc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8erc RCSB], [https://www.ebi.ac.uk/pdbsum/8erc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8erc ProSAT]</span></td></tr> | ||
[[Category: Farese | </table> | ||
[[Category: Liao | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/MBOA7_HUMAN MBOA7_HUMAN] Autosomal recessive non-syndromic intellectual disability. The disease is caused by variants affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/MBOA7_HUMAN MBOA7_HUMAN] Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18094042, PubMed:18772128). Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell (PubMed:18094042, PubMed:18772128). In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation (PubMed:32253259).<ref>PMID:18094042</ref> <ref>PMID:18772128</ref> <ref>PMID:32253259</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Farese RV]] | |||
[[Category: Liao M]] | |||
[[Category: Walther TC]] | |||
[[Category: Wang K]] | |||
Latest revision as of 09:03, 4 June 2025
Human Membrane-bound O-acyltransferase 7
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