9jdu: Difference between revisions
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The | ==The crystal structure of PDE10A complexed with inhibitor 2061== | ||
<StructureSection load='9jdu' size='340' side='right'caption='[[9jdu]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9jdu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JDU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3000176Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EBE:ethyl+2-[1-[4-[2-(diethylaminomethylamino)ethanoyl]quinolin-2-yl]azetidin-3-yl]imidazo[1,2-a]pyridine-3-carboxylate'>A1EBE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jdu OCA], [https://pdbe.org/9jdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jdu RCSB], [https://www.ebi.ac.uk/pdbsum/9jdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jdu ProSAT]</span></td></tr> | ||
[[Category: Guo | </table> | ||
[[Category: Huang | == Function == | ||
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Guo L]] | |||
[[Category: Huang Y-Y]] | |||
[[Category: Luo H-B]] | |||
Latest revision as of 06:18, 25 June 2025
The crystal structure of PDE10A complexed with inhibitor 2061
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