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==Solution NMR Structure of DRBM 2 domain of Interleukin enhancer-binding factor 3 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4527E==
==Solution NMR Structure of DRBM 2 domain of Interleukin enhancer-binding factor 3 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4527E==
<StructureSection load='2l33' size='340' side='right' caption='[[2l33]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2l33' size='340' side='right'caption='[[2l33]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2l33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L33 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2l33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L33 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ILF3, DRBF, MPHOSPH4, NF90 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l33 OCA], [http://pdbe.org/2l33 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l33 RCSB], [http://www.ebi.ac.uk/pdbsum/2l33 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l33 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l33 OCA], [https://pdbe.org/2l33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l33 RCSB], [https://www.ebi.ac.uk/pdbsum/2l33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l33 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ILF3_HUMAN ILF3_HUMAN]] May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).<ref>PMID:7519613</ref> <ref>PMID:9442054</ref>
[https://www.uniprot.org/uniprot/ILF3_HUMAN ILF3_HUMAN] May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).<ref>PMID:7519613</ref> <ref>PMID:9442054</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/2l33_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l3/2l33_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Acton, T B]]
[[Category: Large Structures]]
[[Category: Ciccosanti, A]]
[[Category: Acton TB]]
[[Category: Ciccosanti A]]
[[Category: Everett J]]
[[Category: Janjua H]]
[[Category: Liu G]]
[[Category: Montelione GT]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Everett, J]]
[[Category: Shastry RB]]
[[Category: Janjua, H]]
[[Category: Xiao R]]
[[Category: Liu, G]]
[[Category: Montelione, G T]]
[[Category: Shastry, R B]]
[[Category: Xiao, R]]
[[Category: Drbm]]
[[Category: Dsrna-binding]]
[[Category: Ilf3]]
[[Category: Nf90]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Transcription regulator]]
Retrieved from "https://proteopedia.org/2l33"