9vca: Difference between revisions
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New page: '''Unreleased structure''' The entry 9vca is ON HOLD Authors: Moiseenko, A.V., Kalikin, A.V. Description: Binding site between C-reactive protein and c2cc monoclonal antibody [[Categor... |
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==Binding site between C-reactive protein and c2cc monoclonal antibody== | |||
<StructureSection load='9vca' size='340' side='right'caption='[[9vca]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9vca]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus_albula Mus musculus albula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VCA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vca OCA], [https://pdbe.org/9vca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vca RCSB], [https://www.ebi.ac.uk/pdbsum/9vca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vca ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CRP_HUMAN CRP_HUMAN] Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
C-reactive protein (CRP) plays a central role in innate immunity and serves as a key biomarker of inflammation. Despite its clinical importance, the structural basis of CRP interactions with antibodies remains poorly characterized. Using cryo-electron microscopy (cryo-EM), we resolved the structure of immune complexes formed between pentameric CRP and monoclonal immunoglobulin G (IgG) antibodies at up to 2.4 A resolution. The complexes display a barrel-shaped architecture, with two CRP pentamers bridged by three to five antibodies. We built an atomic model of the CRP-antibody interface, identifying a binding site on the A-face of CRP mediated exclusively by hydrogen bonds, without salt-bridge formation. These findings provide structural insights into CRP-IgG recognition and offer a basis for the rational design of improved antibodies. | |||
Cryo-EM structure of pentameric C-reactive protein in complex with monoclonal IgG antibodies.,Moiseenko AV, Kalikin AV, Orekhov PS, Byzova NA, Zherdev AV, Shaitan KV, Dzantiev BB, Sokolova OS FEBS J. 2025 Oct 29. doi: 10.1111/febs.70310. PMID:41159871<ref>PMID:41159871</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Kalikin | <div class="pdbe-citations 9vca" style="background-color:#fffaf0;"></div> | ||
[[Category: Moiseenko | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus albula]] | |||
[[Category: Kalikin AV]] | |||
[[Category: Moiseenko AV]] | |||
Latest revision as of 07:53, 19 November 2025
Binding site between C-reactive protein and c2cc monoclonal antibody
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