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| <StructureSection load='7ahl' size='350' side='right' caption='α-hemolysin heptamer (PDB code [[7ahl]]).' scene=''> | | <StructureSection load='7ahl' size='350' side='right' caption='α-hemolysin heptamer (PDB code [[7ahl]]).' scene=''> |
| == Function == | | == Function == |
| '''Hemolysin''' (HL) is exotoxin from bacteria which causes lysis of red blood cells<ref>PMID:20110774</ref>. Hemolysin from the bacterium ''Clostridium'' are called '''alpha-toxin''' (AT). AT is a zinc metalloenzyme and binds to the membrane in the presence of calcium. It acts as a phospholipase C. | | '''Hemolysin''' (HL) is exotoxin from bacteria which causes lysis of red blood cells<ref>PMID:20110774</ref>. |
| | *'''alpha-hemolysin''' is a transmembrane pore-forming heptameric molecule<ref>PMID:8943190</ref>. See details for in [[Pore forming toxin, α-hemolysin]]. |
| | *'''delta-hemolysin''' is a 26 amino acid peptide from the bacterium ''Staphylococcus'' exhibiting antimicrobial activity against'' Legionerlla'' <ref>PMID:19150639</ref>. |
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| See details for α-hemolysin in [[Pore forming toxin, α-hemolysin]].
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| See details of hemolysin E in [[Molecular Playground/ClyA]]. | | See details of hemolysin E in [[Molecular Playground/ClyA]]. |
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| </StructureSection> | | </StructureSection> |
| == 3D Structures of hemolysin ==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *α-hemolysin
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| **[[3anz]], [[7ahl]] – SaHL-α – ''Staphylococcus aureus''<br />
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| A full page in Proteopedia exploring [[7ahl]] is found [[Pore_forming_toxin,_α-hemolsyin|here]].<br/>
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| **[[3m2l]], [[3m4d]], [[4p24]], [[4yhd]] - SaHL-α (mutant)<br />
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| **[[3m3r]], [[3m4e]] - SaHL-α (mutant) + β-cyclodextrin<br />
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| **[[4idj]], [[4u6v]] - SaHL-α + antibody<br />
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| *β-hemolysin
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| **[[3k55]] – SaHL-β)<br />
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| **[[3i5v]] - SaHL-β residues 35-330)<br />
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| **[[3i41]] - SaHL-β residues 35-330 (mutant)<br />
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| **[[3i46]], [[3i48]] - SaHL-β residues 35-330 (mutant)<br /> + metal ion
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| *γ-hemolysin
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| **[[2qk7]] – SaHL-γ component A (mutant) +B (mutant)<br />
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| **[[3b07]] - SaHL-γ component A+B<br />
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| **[[4p1x]] - SaHL-γ component B (mutant)+C<br />
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| **[[4p1y]] - SaHL-γ component A + B (mutant)<br />
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| *δ-hemolysin
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| **[[2kam]] – SaHL-δ - NMR
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| *Hemolysin
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| **[[3o44]] – VcHL residues 161-741 – ''Vibrio cholerae''<br />
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| **[[1xez]] – VcHL (mutant)<br />
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| **[[6jkz]], [[6jl0]] - VvHL – ''Vibrio vulnificus''<br />
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| **[[6jl1]], [[6jl2]] - VvHL (mutant)<br />
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| **[[3a57]] – HL 2 – ''Vibrio parahaemolyticus''<br />
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| **[[3hvn]] – HL (mutant) – ''Streptococcus suis''<br />
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| **[[3fy3]], [[5keh]], [[5kf3]], [[4w8q]], [[5kdk]] – PmHL A residues 30-265 – ''Proteus mirabilis''<br />
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| **[[5sz8]], [[5kkd]], [[4w8r]], [[4w8s]], [[4w8t]] - PmHL A residues 30-234 (mutant)<br />
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| **[[1mt0]] – EcHL B ATP-binding domain – ''Escherichia coli''<br />
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| **[[5c21]], [[5c22]] - EcHL D residues 57-333 <br />
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| ** [[6mru]], [[6mrw]], [[6mrt]] – EcHL E – Cryo EM<br />
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| **[[2wcd]] – EcHL E residues 2-303 – ''Escherichia coli''<br />
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| **[[1qoy]], [[4pho]], [[4phq]] - EcHL E (mutant)<br />
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| **[[2oai]], [[2r8d]] – HL corc_hlyc domain – ''Xylella fastidiosa''<br />
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| **[[2r2z]] – HL residues 346-435 – ''Enterococcus faecalis''<br />
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| **[[4wx3]], [[4wx5]] - HL – ''Grimontia hollisae''<br />
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| **[[6d53]], [[6d5z]] - HL C-terminal – ''Bacillus cereus'' - NMR<br />
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| *Alpha-toxin
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| **[[2wxt]], [[1ca1]] - CpAT + Cd + Zn – ''Clostridium perfringens''<br />
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| **[[1qm6]], [[1gyg]], [[1kho]] - CpAT + Zn <br />
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| **[[2wy6]], [[2wxu]] – CpAT (mutant) + Ca + Cd + Zn<br />
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| **[[1qmd]] - CpAT + Ca + Zn<br />
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| **[[1olp]] - AT + Ca + Zn – ''Clostridium absonum''<br />
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| **[[2vk9]] - AT – ''Clostridium novyi''<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
| | [[Category:3D printer files]] |
