9kda: Difference between revisions

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~~'''Unreleased structure'''~~

The entry ~~9kda is ON HOLD~~

==Cryo-EM structure of lipid-mediated dimer of human norepinephrine transporter NET in the presence of the antidepressant vilazodone in an inward-open state at resolution of 2.44 angstrom.==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9kda]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KDA OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9KDA FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.44Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EFM:[(2~{R})-1-[[(2~{S})-2,3-bis(oxidanyl)propoxy]-oxidanyl-phosphoryl]oxy-3-nonanoyloxy-propan-2-yl]+decanoate'>A1EFM</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=YG7:5-[4-[4-(5-cyano-1~{H}-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide'>YG7</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9kda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kda OCA], [https://pdbe.org/9kda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kda RCSB], [https://www.ebi.ac.uk/pdbsum/9kda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kda ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/SC6A2_HUMAN SC6A2_HUMAN] Postural orthostatic tachycardia syndrome due to NET deficiency. The disease is caused by variants affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/SC6A2_HUMAN SC6A2_HUMAN] Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:2008212, PubMed:8125921). Can also mediate sodium- and chloride-dependent transport of dopamine (PubMed:11093780, PubMed:8125921).<ref>PMID:11093780</ref> <ref>PMID:2008212</ref> <ref>PMID:8125921</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Jiang Y]]

[[Category: Xu EH]]

[[Category: Zhang H]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9kda is ON HOLD
+==Cryo-EM structure of lipid-mediated dimer of human norepinephrine transporter NET in the presence of the antidepressant vilazodone in an inward-open state at resolution of 2.44 angstrom.==
+<StructureSection load='9kda' size='340' side='right'caption='[[9kda]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9kda]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KDA FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.44&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EFM:[(2~{R})-1-[[(2~{S})-2,3-bis(oxidanyl)propoxy]-oxidanyl-phosphoryl]oxy-3-nonanoyloxy-propan-2-yl]+decanoate'>A1EFM</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=YG7:5-[4-[4-(5-cyano-1~{H}-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide'>YG7</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kda OCA], [https://pdbe.org/9kda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kda RCSB], [https://www.ebi.ac.uk/pdbsum/9kda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kda ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/SC6A2_HUMAN SC6A2_HUMAN] Postural orthostatic tachycardia syndrome due to NET deficiency. The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/SC6A2_HUMAN SC6A2_HUMAN] Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:2008212, PubMed:8125921). Can also mediate sodium- and chloride-dependent transport of dopamine (PubMed:11093780, PubMed:8125921).<ref>PMID:11093780</ref> <ref>PMID:2008212</ref> <ref>PMID:8125921</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Jiang Y]]
+[[Category: Xu EH]]
+[[Category: Zhang H]]