9ynd: Difference between revisions
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New page: '''Unreleased structure''' The entry 9ynd is ON HOLD Authors: Yang, J., Rao, Q., Chai, P., Zhang, K. Description: Motor domain of human dynein-1 in pre-power stroke bound to dynactin-p... |
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==Motor domain of human dynein-1 in pre-power stroke bound to dynactin-p150glued-CC1B and LIS1== | |||
<StructureSection load='9ynd' size='340' side='right'caption='[[9ynd]], [[Resolution|resolution]] 4.26Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ynd]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YND FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.26Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ynd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ynd OCA], [https://pdbe.org/9ynd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ynd RCSB], [https://www.ebi.ac.uk/pdbsum/9ynd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ynd ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Rao | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/DYHC1_HUMAN DYHC1_HUMAN] Autosomal dominant childhood-onset proximal spinal muscular atrophy without contractures;Autosomal dominant non-syndromic intellectual disability;Autosomal dominant Charcot-Marie-Tooth disease type 2O. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | |||
[https://www.uniprot.org/uniprot/DYHC1_HUMAN DYHC1_HUMAN] Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074).<ref>PMID:27462074</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chai P]] | |||
[[Category: Rao Q]] | |||
[[Category: Yang J]] | |||
[[Category: Zhang K]] | |||
Latest revision as of 14:50, 10 February 2026
Motor domain of human dynein-1 in pre-power stroke bound to dynactin-p150glued-CC1B and LIS1
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