9d62: Difference between revisions
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==Crystal structure of Human Galectin-3 CRD in complex with Lactose (native)== | |||
<StructureSection load='9d62' size='340' side='right'caption='[[9d62]], [[Resolution|resolution]] 1.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9d62]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9D62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9D62 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9d62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9d62 OCA], [https://pdbe.org/9d62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9d62 RCSB], [https://www.ebi.ac.uk/pdbsum/9d62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9d62 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Albuquerque LJC]] | ||
[[Category: | [[Category: Amaral SS]] | ||
[[Category: | [[Category: Baruffi MR]] | ||
[[Category: Dias IP]] | |||
[[Category: Mazepa E]] | |||
[[Category: Mestriner L]] | |||
[[Category: Minella TF]] | |||
[[Category: Mischiatti KL]] | |||
[[Category: Nascimento AFZ]] | |||
[[Category: Picheth GF]] | |||
[[Category: Silveira JLM]] | |||
[[Category: Winnischofer SMB]] | |||
[[Category: Dos Santos LV]] | |||
Latest revision as of 07:26, 19 March 2026
Crystal structure of Human Galectin-3 CRD in complex with Lactose (native)
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