Netrin: Difference between revisions

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<StructureSection load='4ove' size='340' side='right' caption='Glycosylated mouse netrin-1 complex with Ca+2 and Cl-1 ions (PDB code [[4ove]])' scene=''>
<StructureSection load='4ove' size='350' side='right' caption='Glycosylated mouse netrin-1 complex with Ca+2 and Cl-1 ions (PDB code [[4ove]])' scene='' pspeed='8'>
'''Netrins''' (Net) direct cell and axon migration during development.  Netrins are chemotropic.  The growing axon moves either toward or away from netrin concentration.  Netrins influence the formation of a variety of tissues.  They act as chemoattractants for some cell types and chemorepellent for other types.
 
== Function ==
== Function ==
 
'''Netrins''' (Net) direct cell and axon migration during development.  Netrins are chemotropic.  The growing axon moves either toward or away from netrin concentration.  Netrins influence the formation of a variety of tissues.  They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>. 
== Disease ==
*'''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein.
*'''Netrin-4''' promotes neurite elongation at low concentration and inhibits neurite elongation at high concentration<ref>PMID:19094984</ref>.
*'''Netrin-G1''' promotes the growth of dorsal thalamic axons.
*'''Netrin-G2''' plays a role in synaptic and pre-synaptic organisation<ref>PMID:31668703</ref>.


== Relevance ==
== Relevance ==
Netrin-1 is over-expressed in glioblastoma tumor<ref>PMID:23549787</ref>.  Netrin-1 is a therapeutic target in cardiovascular diseases<ref>PMID:26209250</ref>.


== Structural highlights ==
== Structural highlights ==
 
The N-terminal of netrin-1 is homologous to the N-terminal type I domain of laminin (LN) followed by 3 cysteine-rich epidermal growth factor repeats.
*<scene name='70/705761/Cv/3'>Ca coordination site</scene>. Water molecules are shown as red spheres.
*<scene name='70/705761/Cv/4'>Cl coordination site</scene>.
</StructureSection>
</StructureSection>


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*Netrin-1
*Netrin-1


**[[7ne1]] – hNet1 V-VI domains 39-453 + neogenin - human<BR />
**[[7ne0]] – hNet1 V-VI domains + neogenin + RGMB<BR />
**[[7ndg]] – hNet1 V-VI domains + neogenin + RGMB – Cryo EM<BR />
**[[4urt]] – hNet1 V-VI domains + hNet receptor DCC fourth fibronectin type FN5-FN6 domains <BR />
**[[6fkq]] – hNet1 V-VI domains + draxin peptide<BR />
**[[4ove]] – mNet1 – mouse<BR />
**[[4ove]] – mNet1 – mouse<BR />
**[[4plm]] – cNet1 LN-LE3 domains – chicken<BR />
**[[9d77]] – cNet1 – chicken<BR />
**[[8tsm]] – cNet1 LN-LE2 domains 26-405 <BR />
**[[4plm]], [[7ler]] – cNet1 LN-LE3 domains 26-457 – chicken<BR />
**[[4pln]] – cNet1 LN-LE3 domains + neogenin fibronectin type IV-V domains<br />
**[[4pln]] – cNet1 LN-LE3 domains + neogenin fibronectin type IV-V domains<br />
**[[4plo]] – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains <BR />
**[[4plo]] – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains <BR />
**[[4urt]] – hNet1 LN-LE3 domains + hNet receptor DCC fourth fibronectin type V-VI domains - human<BR />
**[[7lrf]] – cNet1 LN-LE3 domains + SOS<br />
 
*Netrin-4
 
**[[4wnx]] – mNet4<BR />
**[[9az3]] – mNet4 43-326 + laminin subunit gamma – Cryo EM<BR />
 
*Netrin-G1
 
**[[3zyj]] – hNetG1 LAM + EGF1 domains (mutant) + leucine-rich repeat-containing protein<BR />


*Netrin-G2
*Netrin-G2
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== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
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