Netrin: Difference between revisions
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<StructureSection load='4ove' size=' | <StructureSection load='4ove' size='350' side='right' caption='Glycosylated mouse netrin-1 complex with Ca+2 and Cl-1 ions (PDB code [[4ove]])' scene='' pspeed='8'> | ||
== Function == | == Function == | ||
'''Netrins''' (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>. '''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein. | '''Netrins''' (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>. | ||
*'''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein. | |||
*'''Netrin-4''' promotes neurite elongation at low concentration and inhibits neurite elongation at high concentration<ref>PMID:19094984</ref>. | |||
*'''Netrin-G1''' promotes the growth of dorsal thalamic axons. | |||
*'''Netrin-G2''' plays a role in synaptic and pre-synaptic organisation<ref>PMID:31668703</ref>. | |||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
The N-terminal of netrin-1 is homologous to the N-terminal type I domain of laminin (LN) followed by 3 cysteine-rich epidermal growth factor repeats. | The N-terminal of netrin-1 is homologous to the N-terminal type I domain of laminin (LN) followed by 3 cysteine-rich epidermal growth factor repeats. | ||
*<scene name='70/705761/Cv/ | *<scene name='70/705761/Cv/3'>Ca coordination site</scene>. Water molecules are shown as red spheres. | ||
*<scene name='70/705761/Cv/ | *<scene name='70/705761/Cv/4'>Cl coordination site</scene>. | ||
</StructureSection> | </StructureSection> | ||
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*Netrin-1 | *Netrin-1 | ||
**[[7ne1]] – hNet1 V-VI domains 39-453 + neogenin - human<BR /> | |||
**[[7ne0]] – hNet1 V-VI domains + neogenin + RGMB<BR /> | |||
**[[7ndg]] – hNet1 V-VI domains + neogenin + RGMB – Cryo EM<BR /> | |||
**[[4urt]] – hNet1 V-VI domains + hNet receptor DCC fourth fibronectin type FN5-FN6 domains <BR /> | |||
**[[6fkq]] – hNet1 V-VI domains + draxin peptide<BR /> | |||
**[[4ove]] – mNet1 – mouse<BR /> | **[[4ove]] – mNet1 – mouse<BR /> | ||
**[[4plm]] – cNet1 LN-LE3 domains – chicken<BR /> | **[[9d77]] – cNet1 – chicken<BR /> | ||
**[[8tsm]] – cNet1 LN-LE2 domains 26-405 <BR /> | |||
**[[4plm]], [[7ler]] – cNet1 LN-LE3 domains 26-457 – chicken<BR /> | |||
**[[4pln]] – cNet1 LN-LE3 domains + neogenin fibronectin type IV-V domains<br /> | **[[4pln]] – cNet1 LN-LE3 domains + neogenin fibronectin type IV-V domains<br /> | ||
**[[4plo]] – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains <BR /> | **[[4plo]] – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains <BR /> | ||
**[[ | **[[7lrf]] – cNet1 LN-LE3 domains + SOS<br /> | ||
*Netrin-4 | *Netrin-4 | ||
**[[4wnx]] – mNet4<BR /> | **[[4wnx]] – mNet4<BR /> | ||
**[[9az3]] – mNet4 43-326 + laminin subunit gamma – Cryo EM<BR /> | |||
*Netrin-G1 | |||
**[[3zyj]] – hNetG1 LAM + EGF1 domains (mutant) + leucine-rich repeat-containing protein<BR /> | |||
*Netrin-G2 | *Netrin-G2 | ||
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== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
