NEDD8: Difference between revisions

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[[Image:1ndd.png|left|200px|thumb|Crystal Structure of NEDD8, [[1ndd]]]]
<StructureSection load='1ndd' size='350' side='right' scene='42/420012/Cv/5' caption='Human NEDD8 complex with sulfate and Cl- (green) ions, [[1ndd]]' pspeed='8'>
{{STRUCTURE_1ndd|  PDB=1ndd  | SIZE=300| SCENE=NEDD8/Cv/1 |right|CAPTION=NEDD8, [[1ndd]] }}


[[NEDD8]] is a ubiquitin-like protein in human.  It facilitates ubiquitin conjugation.  It participates in the recruitment of E2 to the ubiquitin ligase complex.  NEDD8 modifies the cullin subunits (CUL) of SCF ubiquitin E3 ligase.  In yeast the protein is called Rub1. The images at the left and at the right correspond to one representative NEDD8, ''i.e.'' the crystal structure of NEDD8 ([[1ndd]]). Cl and SO4 are shown as space filling objects. 
{{TOC limit|limit=2}}


[[NEDD8]] is a ubiquitin-like protein in humans.  It facilitates ubiquitin conjugation.  It participates in the recruitment of E2 to the ubiquitin ligase complex.  NEDD8 modifies the cullin subunits (CUL) of SCF ubiquitin E3 ligase<ref>PMID:15180522</ref>.  In yeast the protein is called '''Rub1'''.
*<scene name='42/420012/Cv/4'>Cl coordination site is located between 2 monomers</scene>. Water molecules are shown as red spheres. 
</StructureSection>
== 3D Structures of NEDD8 ==
== 3D Structures of NEDD8 ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


=== NEDD8 ===
* NEDD8  
 
 
[[1ndd]] - hNEDD8 - human<br />
[[2ko3]] – hNEDD8 – NMR<br />
 
 
=== NEDD8+ubiquitin-activating enzyme E1 ===
 
 
[[3gzn]] – hNEDD8+hE1 regulatory and catalytic subunits<br />
[[3dbh]], [[3dbl]], [[3dbr]] - hNEDD8+hE1 regulatory and catalytic subunits (mutant)<br />
[[2nvu]] - hNEDD8+hE1 regulatory subunit+MBP/E1 catalytic subunit+UBC12<br />
[[1r4m]] - hNEDD8+hE1C+amyloid beta precursor protein<br />
[[1r4n]] - hNEDD8+hE1C+amyloid beta precursor protein+ATP<br />
 
 
=== NEDD8+other proteins ===


**[[1ndd]] - hNEDD8 - human<br />
**[[2ko3]] – hNEDD8 – NMR<br />


[[3dqv]] – hNEDD8+CUL-5 <br />
* NEDD8+ubiquitin-activating enzyme E1
[[2bkr]] – hNEDD8+NEDP1<br />
[[1xt9]] – hNEDD8+DEN1<br />


**[[3gzn]] – hNEDD8+hE1 regulatory and catalytic subunits<br />
**[[3dbh]], [[3dbl]], [[3dbr]] - hNEDD8+hE1 regulatory and catalytic subunits (mutant)<br />
**[[2nvu]] - hNEDD8+hE1 regulatory subunit+MBP/E1 catalytic subunit+UBC12<br />
**[[1r4m]] - hNEDD8+hE1C+amyloid beta precursor protein<br />
**[[1r4n]] - hNEDD8+hE1C+amyloid beta precursor protein+ATP<br />


=== Rub1 ===
* NEDD8+other proteins


**[[3dqv]] – hNEDD8+CUL-5 <br />
**[[8caf]] – hNEDD8 + Cul-1 + antibody<br />
**[[2bkr]] – hNEDD8+NEDP1<br />
**[[1xt9]] – hNEDD8+DEN1<br />
**[[4f8c]] – hNEDD8 + cycle inhibiting factor<br />
**[[4hcp]] – hNEDD8 + ATP/GTP binding protein<br />
**[[4fbj]] – hNEDD8 + bacterial effector CIF<br />
**[[4p5o]] – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + DCN1-like protein + UBC12<br />
**[[7oni]] – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + ring-box protein – Cryo EM<br />
**[[7b5n]] – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + polyubiquitin – Cryo EM<br />
**[[7b5l]] – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + polyubiquitin + S-phase kinase-associated protein + CKS-1 – Cryo EM<br />
**[[8wzn]], [[8wzo]] – hNEDD8 + E3 ubiquitin-protein ligase parkin<br />
**[[6ttu]] – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + F-box/WD repeat containing protein + SKP – Cryo EM<br />
**[[8wqc]], [[8wqg]] – hNEDD8 + hCul2 + elongin-B + elongin-C + RBX1 + FEM1B – Cryo EM<br />
**[[8r5h]], [[8rx0]] – hNEDD8 + hCul2 + elongin-B + elongin-C + RBX1 + polyubiquitin + ubiquitin-conjugating enzyme E2 + PVHL + HUNK1 – Cryo EM<br />
**[[8b3i]] – hNEDD8 + hCul4A + RBX1 + polyubiquitin + ubiquitin-conjugating enzyme E2 +ERCC-8 + DNA damage-binding protein – Cryo EM<br />
**[[8b3g]] – hNEDD8 + hCul4A + RBX1 + polyubiquitin + ubiquitin-conjugating enzyme E2 +ERCC-8 + DNA damage-binding protein + UV-stimulated scaffold protein – Cryo EM<br />
**[[9sdx]] – hNEDD8 + hCul5 + RBX1 + ubiquitin + ARIH2 + L3A2 – Cryo EM<br />
**[[8q7h]] – hNEDD8 + hCul9 + RBX1 – Cryo EM<br />
**[[6r7f]], [[8h38]], [[9efm]], [[9efq]], [[9efv]], [[9eg1]], [[9egl]] – hNEDD8 in signalosome – Cryo EM<br />


[[1bt0]] – Rub1 – ''Arabidopsis thaliana''<br />
* Rub1  


**[[1bt0]] – Rub1 – ''Arabidopsis thaliana''<br />


}}
== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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