Nebulin: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) New page: <StructureSection load='1neb' size='350' side='right' caption='NMR structure of human nebulin SH3 domain (PDB entry 1neb)' scene=''> '''Nebulin''' is an actin-binding protein whic... |
Michal Harel (talk | contribs) No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='1neb' size='350' side='right' caption='NMR structure of human nebulin SH3 domain (PDB entry [[1neb]])' scene=''> | |||
== Function == | |||
'''Nebulin''' is an actin-binding protein which can bind upto 200 actin molecules. Nebulin length is proportional to the length of the thin filament. It may function as a regulator of thin filament length during sarcomere assembly<ref>PMID:21115852</ref>. | |||
For more details see [[Group:MUZIC:Nebulin]]. | |||
== Disease == | |||
Mutations in nebulin were identified in patients with nemaline myopathy<ref>PMID:11257471</ref>. | |||
==3D structures of nebulin== | ==3D structures of nebulin== | ||
| Line 10: | Line 14: | ||
[[1neb]] – hNebulin SH3 domain residues 918-977 – human - NMR <br /> | [[1neb]] – hNebulin SH3 domain residues 918-977 – human - NMR <br /> | ||
[[1ark]] – hNebulin SH3 domain residues 6610-6669 - NMR <br /> | [[1ark]] – hNebulin SH3 domain residues 6610-6669 - NMR <br /> | ||
[[7qin]] – mNebulin in actomyosin complex – mouse – Cryo EM<br /> | |||
[[7qim]] – mNebulin + actin – Cryo EM<br /> | |||
[[8g2z]], [[8g3d]], [[8sf7]] – Nebulin in microtubule – ''Tetrahymena thermophila'' – Cryo EM<br /> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | |||
