9wfc: Difference between revisions
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New page: '''Unreleased structure''' The entry 9wfc is ON HOLD Authors: Qian, H.W., Zhang, W.J. Description: Cryo-EM structure of GGCX-MGP complex Category: Unreleased Structures [[Category:... |
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==Cryo-EM structure of GGCX-MGP complex== | |||
<StructureSection load='9wfc' size='340' side='right'caption='[[9wfc]], [[Resolution|resolution]] 3.33Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9wfc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9WFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9WFC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.33Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AT1:(1aR,7aS)-1a-methyl-7a-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl]-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione'>A1AT1</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=MX7:(2R)-3-(PHOSPHONOOXY)PROPANE-1,2-DIYL+(9Z,9Z)BIS-OCTADEC-9-ENOATE'>MX7</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr> | ||
[[Category: Qian | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9wfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9wfc OCA], [https://pdbe.org/9wfc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9wfc RCSB], [https://www.ebi.ac.uk/pdbsum/9wfc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9wfc ProSAT]</span></td></tr> | ||
[[Category: Zhang | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/VKGC_HUMAN VKGC_HUMAN] Pseudoxanthoma elasticum-like skin manifestations with retinitis pigmentosa;Hereditary combined deficiency of vitamin K-dependent clotting factors;Body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/VKGC_HUMAN VKGC_HUMAN] Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide (PubMed:17073445). Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP) (PubMed:17073445).<ref>PMID:17073445</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Qian HW]] | |||
[[Category: Zhang WJ]] | |||
Latest revision as of 16:06, 1 April 2026
Cryo-EM structure of GGCX-MGP complex
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