9qs2: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
New page: '''Unreleased structure''' The entry 9qs2 is ON HOLD Authors: Benz, L.S., Becker, F., Janssen, P., Fuesser, F.T., Weiss, M.S., Kuemmel, D., Koch, O. Description: Crystal structure of Z...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 9qs2 is ON HOLD
==Crystal structure of Zika Virus NS2B-NS3 protease in complex with Z100582766==
 
<StructureSection load='9qs2' size='340' side='right'caption='[[9qs2]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
Authors: Benz, L.S., Becker, F., Janssen, P., Fuesser, F.T., Weiss, M.S., Kuemmel, D., Koch, O.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9qs2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QS2 FirstGlance]. <br>
Description: Crystal structure of Zika Virus NS2B-NS3 protease in complex with Z100582766
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1I9X:1-methyl-~{N}-(pyridin-2-ylmethyl)pyrazole-4-carboxamide'>A1I9X</scene></td></tr>
[[Category: Koch, O]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qs2 OCA], [https://pdbe.org/9qs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qs2 RCSB], [https://www.ebi.ac.uk/pdbsum/9qs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qs2 ProSAT]</span></td></tr>
[[Category: Benz, L.S]]
</table>
[[Category: Janssen, P]]
== Function ==
[[Category: Weiss, M.S]]
[https://www.uniprot.org/uniprot/POLG_ZIKV POLG_ZIKV] Protein C: Encapsulates the genomic RNA.[UniProtKB:P17763]  prM: Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.[UniProtKB:P17763]  Envelope protein E: Binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.[UniProtKB:P17763]  Non-structural protein 1: Involved in virus replication and regulation of the innate immune response.[UniProtKB:P17763]  Non-structural protein 2A: May be involved viral RNA replication and capsid assembly.[UniProtKB:P09732]  Non-structural protein 4A: Induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the helicase region of Serine protease NS3 chain.[UniProtKB:P17763]  Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763]  Non-structural protein 4B: Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:P17763]
[[Category: Fuesser, F.T]]
__TOC__
[[Category: Becker, F]]
</StructureSection>
[[Category: Kuemmel, D]]
[[Category: Large Structures]]
[[Category: Zika virus]]
[[Category: Becker F]]
[[Category: Benz LS]]
[[Category: Fuesser FT]]
[[Category: Janssen P]]
[[Category: Koch O]]
[[Category: Kuemmel D]]
[[Category: Weiss MS]]
Retrieved from "https://proteopedia.org/9qs2"