9tpd: Difference between revisions

(One intermediate revision by the same user not shown)

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9tpd is ~~ON HOLD~~

==Crystal structure of integrin-linked kinase (ILK) in complex with alpha-parvin and a cyano-quinoline ligand==

~~Authors~~: ~~Abdul Azeez~~, K.R., ~~Greco~~, F.A., ~~Knapp~~, S.

== Structural highlights ==

<table><tr><td colspan='2'>[[9tpd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9TPD OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9TPD FirstGlance].

~~Description~~: ~~Crystal structure~~ of integrin-~~linked kinase (ILK)~~ in ~~complex with alpha~~-~~parvin~~ and ~~a cyano~~-~~quinoline ligand~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JW7:4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-6-piperazin-1-yl-quinoline-3-carbonitrile'>A1JW7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>

[[Category: ~~Knapp, S~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9tpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9tpd OCA], [https://pdbe.org/9tpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9tpd RCSB], [https://www.ebi.ac.uk/pdbsum/9tpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9tpd ProSAT]</td></tr>

[[Category: Abdul Azeez~~, K.R~~]]

</table>

[[Category: Greco~~, F.A~~]]

== Function ==

[https://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Abdul Azeez KR]]

[[Category: Greco FA]]

[[Category: Knapp S]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9tpd is ON HOLD
+==Crystal structure of integrin-linked kinase (ILK) in complex with alpha-parvin and a cyano-quinoline ligand==
+<StructureSection load='9tpd' size='340' side='right'caption='[[9tpd]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-Authors: Abdul Azeez, K.R., Greco, F.A., Knapp, S.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9tpd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9TPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9TPD FirstGlance]. <br>
-Description: Crystal structure of integrin-linked kinase (ILK) in complex with alpha-parvin and a cyano-quinoline ligand
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JW7:4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-6-piperazin-1-yl-quinoline-3-carbonitrile'>A1JW7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-[[Category: Knapp, S]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9tpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9tpd OCA], [https://pdbe.org/9tpd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9tpd RCSB], [https://www.ebi.ac.uk/pdbsum/9tpd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9tpd ProSAT]</span></td></tr>
-[[Category: Abdul Azeez, K.R]]
+</table>
-[[Category: Greco, F.A]]
+== Function ==
+[https://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Abdul Azeez KR]]
+[[Category: Greco FA]]
+[[Category: Knapp S]]