Cart: Difference between revisions
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==Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide== | ==Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide== | ||
<StructureSection load='1hy9' size='340' side='right' caption='Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide' scene=' | <StructureSection load='1hy9' size='340' side='right' caption='Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide (PDB code [[1hy9]])' scene=''> | ||
'''CART''' (Cocaine- and Amphetamine-Regulated Transcript) is a neuropeptide found primarily in the hypothalamus of the brain, where it plays an important role in regulating appetite and energy balance. CART expression increases after cocaine or amphetamine exposure, but it is now best known as an '''anorectic (appetite-suppressing) peptide''' regulated by the hormone leptin. Injections of CART into the brain reduce normal feeding, starvation-induced feeding, and block the strong feeding response caused by neuropeptide Y (NPY). | '''CART''' (Cocaine- and Amphetamine-Regulated Transcript) is a neuropeptide found primarily in the hypothalamus of the brain, where it plays an important role in regulating appetite and energy balance. CART expression increases after cocaine or amphetamine exposure, but it is now best known as an '''anorectic (appetite-suppressing) peptide''' regulated by the hormone leptin. Injections of CART into the brain reduce normal feeding, starvation-induced feeding, and block the strong feeding response caused by neuropeptide Y (NPY). | ||
The biologically active region of CART is a small, disulfide-rich C-terminal fragment (residues 48–89), whose three-dimensional structure reveals a compact scaffold stabilized by '''three disulfide bonds'''. | The biologically active region of CART is a small, disulfide-rich C-terminal fragment (residues 48–89), whose three-dimensional structure reveals a compact scaffold stabilized by '''three disulfide bonds'''. | ||
