Granzyme: Difference between revisions
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<StructureSection load=' | <StructureSection load='1iau' size='400' side='right' caption='Structure of glycosylated human granzyme B (green) complex with pentapeptide inhibitor (magenta) and Zn+2 ions (grey) (PDB entry [[1iau]])' scene='51/517375/Cv/1'> | ||
== Function == | |||
'''Granzymes''' (GZM) are serine proteases which induce apoptosis in virus-infected cells<ref>PMID:17158907</ref>.<br /> | '''Granzymes''' (GZM) or '''cytotoxic T-lymphocyte proteinase 1''' are serine proteases which induce apoptosis in virus-infected cells<ref>PMID:17158907</ref>.<br /> | ||
*'''Granzyme A | *'''Granzyme A''' is the most abundant serine protease in killer cells cytotoxic granules <ref>PMID:20536557</ref>.<br /> | ||
*'''Granzyme B and C''' | *'''Granzyme B and C''' induce cytotoxic T lymphocyte-mediated target cell apoptosis <ref>PMID:12752668</ref>.<br /> | ||
*'''Granzyme H''' helps granzyme B kill adenovirus-infected cells <ref>PMID:17766182</ref>.<br /> | *'''Granzyme H''' helps granzyme B kill adenovirus-infected cells <ref>PMID:17766182</ref>.<br /> | ||
*'''Granzyme K''' functions in a similar way to granzyme A <ref>PMID:19059912</ref>.<br /> | |||
*'''Granzyme M''' induces target cell death, inhibits viral replication and regulates inflammation <ref>PMID:24413154</ref>.<br /> | *'''Granzyme M''' induces target cell death, inhibits viral replication and regulates inflammation <ref>PMID:24413154</ref>.<br /> | ||
== Structural highlights == | |||
The <scene name='51/517375/Cv/6'>active site</scene> of human GZMB contains the <scene name='51/517375/Cv/7'>typical serine protease catalytic triad</scene> and <scene name='51/517375/Cv/8'>oxyanion hole</scene><ref>PMID:11325591</ref>. | |||
</StructureSection> | </StructureSection> | ||
