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[[Image:1m77.png|left|200px]]


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==Near Atomic Resolution Crystal Structure of an A-DNA Decamer d(CCCGATCGGG): Cobalt Hexammine Interactions with A-DNA==
The line below this paragraph, containing "STRUCTURE_1m77", creates the "Structure Box" on the page.
<StructureSection load='1m77' size='340' side='right'caption='[[1m77]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1m77]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M77 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
{{STRUCTURE_1m77|  PDB=1m77  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m77 OCA], [https://pdbe.org/1m77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m77 RCSB], [https://www.ebi.ac.uk/pdbsum/1m77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m77 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of the DNA decamer d(CCCGATCGGG) has been determined at 1.25 A resolution. The decamer crystallized in the tetragonal space group P4(3)2(1)2, with unit-cell parameters a = b = 44.3, c = 24.8 A and one strand in the asymmetric unit. The structure was solved by the molecular-replacement method and refined to R(work) and R(free) values of 16.3 and 18.5%, respectively, for 5969 reflections. The decamer forms the A-form DNA duplex, with the abutting crystal packing typical of A-DNA. The crystal packing interactions seem to distort the local conformation: A5 adopts the trans/trans conformation for the torsion angles alpha and gamma instead of the usual gauche(-)/gauche(+) conformations, yielding G*(G.C) base triplets. The highly hydrated [Co(NH(3))(6)](3+) ion adopts a novel binding mode to the DNA duplex, binding directly to phosphate groups and connecting to N7 and O6 atoms of guanines by water bridges. Analysis of thermal parameters (B factors) shows that the nucleotides involved in abutting crystal packing are thermally more stable than other nucleotides in the duplex.


===Near Atomic Resolution Crystal Structure of an A-DNA Decamer d(CCCGATCGGG): Cobalt Hexammine Interactions with A-DNA===
Near-atomic resolution crystal structure of an A-DNA decamer d(CCCGATCGGG): cobalt hexammine interaction with A-DNA.,Ramakrishnan B, Sekharudu C, Pan B, Sundaralingam M Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):67-72. Epub 2002, Dec 19. PMID:12499541<ref>PMID:12499541</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_12499541}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1m77" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 12499541 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_12499541}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M77 OCA].
[[Category: Pan BC]]
 
[[Category: Ramakrishnan B]]
==Reference==
[[Category: Sekharudu C]]
Near-atomic resolution crystal structure of an A-DNA decamer d(CCCGATCGGG): cobalt hexammine interaction with A-DNA., Ramakrishnan B, Sekharudu C, Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):67-72. Epub 2002, Dec 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12499541 12499541]
[[Category: Sundaralingam M]]
[[Category: Pan, B C.]]
[[Category: Ramakrishnan, B.]]
[[Category: Sekharudu, C.]]
[[Category: Sundaralingam, M.]]
[[Category: A-dna]]
[[Category: Cobalt hexammine]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  2 23:22:00 2008''

Latest revision as of 06:34, 13 August 2026

Near Atomic Resolution Crystal Structure of an A-DNA Decamer d(CCCGATCGGG): Cobalt Hexammine Interactions with A-DNA

1m77, resolution 1.25Å

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