3bnt: Difference between revisions

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{{Seed}}
[[Image:3bnt.png|left|200px]]


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==Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site in the Presence of [Co(NH3)6]Cl3 (A1555G mutant, Br-derivative)==
The line below this paragraph, containing "STRUCTURE_3bnt", creates the "Structure Box" on the page.
<StructureSection load='3bnt' size='340' side='right'caption='[[3bnt]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3bnt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BNT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BNT FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BU:5-BROMO-URIDINE-5-MONOPHOSPHATE'>5BU</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
{{STRUCTURE_3bnt|  PDB=3bnt  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bnt OCA], [https://pdbe.org/3bnt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bnt RCSB], [https://www.ebi.ac.uk/pdbsum/3bnt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bnt ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The A site of the small ribosomal subunit participates in the fidelity of decoding by switching between two states, a resting 'off' state and an active decoding 'on' state. Eight crystal structures of RNA duplexes containing two minimal decoding A sites of the Homo sapiens mitochondrial wild-type, the A1555G mutant or bacteria have been solved. The resting 'off' state of the mitochondrial wild-type A site is surprisingly different from that of the bacterial A site. The mitochondrial A1555G mutant has two types of the 'off' states; one is similar to the mitochondrial wild-type 'off' state and the other is similar to the bacterial 'off' state. Our present results indicate that the dynamics of the A site in bacteria and mitochondria are different, a property probably related to the small number of tRNAs used for decoding in mitochondria. Based on these structures, we propose a hypothesis for the molecular mechanism of non-syndromic hearing loss due to the mitochondrial A1555G mutation.


===Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site in the Presence of [Co(NH3)6]Cl3 (A1555G mutant, Br-derivative)===
The bacterial and mitochondrial ribosomal A-site molecular switches possess different conformational substates.,Kondo J, Westhof E Nucleic Acids Res. 2008 May;36(8):2654-66. Epub 2008 Mar 16. PMID:18346970<ref>PMID:18346970</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3bnt" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 18346970 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_18346970}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
3BNT is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BNT OCA].
[[Category: Kondo J]]
 
[[Category: Westhof E]]
==Reference==
The bacterial and mitochondrial ribosomal A-site molecular switches possess different conformational substates., Kondo J, Westhof E, Nucleic Acids Res. 2008 May;36(8):2654-66. Epub 2008 Mar 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18346970 18346970]
[[Category: Single protein]]
[[Category: Kondo, J.]]
[[Category: Westhof, E.]]
[[Category: Decoding site]]
[[Category: Ribosome]]
[[Category: Rna]]
 
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