3qcd: Difference between revisions

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[[Image:3qcd.jpg|left|200px]]


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==Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, trigonal crystal form==
The line below this paragraph, containing "STRUCTURE_3qcd", creates the "Structure Box" on the page.
<StructureSection load='3qcd' size='340' side='right'caption='[[3qcd]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3qcd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QCD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
{{STRUCTURE_3qcd|  PDB=3qcd  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qcd OCA], [https://pdbe.org/3qcd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qcd RCSB], [https://www.ebi.ac.uk/pdbsum/3qcd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qcd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTPRG_HUMAN PTPRG_HUMAN] Possesses tyrosine phosphatase activity.<ref>PMID:19167335</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Protein tyrosine phosphatases (PTPs) catalyze the dephosphorylation of tyrosine residues, a process that involves a conserved tryptophan-proline-aspartate (WPD) loop in catalysis. In previously determined structures of PTPs, the WPD-loop has been observed in either an "open" conformation or a "closed" conformation. In the current work, X-ray structures of the catalytic domain of receptor-like protein tyrosine phosphatase gamma (RPTPgamma) revealed a ligand-induced "superopen" conformation not previously reported for PTPs. In the superopen conformation, the ligand acts as an apparent competitive inhibitor and binds in a small hydrophobic pocket adjacent to, but distinct from, the active site. In the open and closed WPD-loop conformations of RPTPgamma, the side chain of Trp1026 partially occupies this pocket. In the superopen conformation, Trp1026 is displaced allowing a 3,4-dichlorobenzyl substituent to occupy this site. The bound ligand prevents closure of the WPD-loop over the active site and disrupts the catalytic cycle of the enzyme.


===Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with vanadate, trigonal crystal form===
Small molecule receptor protein tyrosine phosphatase gamma (RPTPgamma) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.,Sheriff S, Beno BR, Zhai W, Kostich WA, McDonnell PA, Kish K, Goldfarb V, Gao M, Kiefer SE, Yanchunas J, Huang Y, Shi S, Zhu S, Dzierba C, Bronson J, Macor JE, Appiah KK, Westphal RS, O'Connell J, Gerritz SW J Med Chem. 2011 Oct 13;54(19):6548-62. Epub 2011 Sep 20. PMID:21882820<ref>PMID:21882820</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3qcd" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_21882820}}, adds the Publication Abstract to the page
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 21882820 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21882820}}
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</StructureSection>
==About this Structure==
[[3qcd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QCD OCA].
 
==Reference==
<ref group="xtra">PMID:021882820</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Large Structures]]
[[Category: Sheriff, S.]]
[[Category: Sheriff S]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Twisted mixed beta-sheets flanked by {alpha}-helice]]
[[Category: Tyrosine receptor phosphatase]]
Retrieved from "https://proteopedia.org/3qcd"