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New page: '''Unreleased structure''' The entry 3tom is ON HOLD Authors: Brodin, J.B., Tezcan, F.A. Description: Crystal structure of an engineered cytochrome cb562 that forms 2D, Zn-mediated she...
 
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'''Unreleased structure'''


The entry 3tom is ON HOLD
==Crystal structure of an engineered cytochrome cb562 that forms 2D, Zn-mediated sheets==
<StructureSection load='3tom' size='340' side='right'caption='[[3tom]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3tom]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The September 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Designed Protein Cages''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_9 10.2210/rcsb_pdb/mom_2013_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TOM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tom OCA], [https://pdbe.org/3tom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tom RCSB], [https://www.ebi.ac.uk/pdbsum/3tom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tom ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Proteins represent the most sophisticated building blocks available to an organism and to the laboratory chemist. Yet, in contrast to nearly all other types of molecular building blocks, the designed self-assembly of proteins has largely been inaccessible because of the chemical and structural heterogeneity of protein surfaces. To circumvent the challenge of programming extensive non-covalent interactions to control protein self-assembly, we have previously exploited the directionality and strength of metal coordination interactions to guide the formation of closed, homoligomeric protein assemblies. Here, we extend this strategy to the generation of periodic protein arrays. We show that a monomeric protein with properly oriented coordination motifs on its surface can arrange, on metal binding, into one-dimensional nanotubes and two- or three-dimensional crystalline arrays with dimensions that collectively span nearly the entire nano- and micrometre scale. The assembly of these arrays is tuned predictably by external stimuli, such as metal concentration and pH.


Authors: Brodin, J.B., Tezcan, F.A.
Metal-directed, chemically tunable assembly of one-, two- and three-dimensional crystalline protein arrays.,Brodin JD, Ambroggio XI, Tang C, Parent KN, Baker TS, Tezcan FA Nat Chem. 2012 Mar 4;4(5):375-82. doi: 10.1038/nchem.1290. PMID:22522257<ref>PMID:22522257</ref>


Description: Crystal structure of an engineered cytochrome cb562 that forms 2D, Zn-mediated sheets
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3tom" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Cytochrome b5 3D structures|Cytochrome b5 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Designed Protein Cages]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Brodin JB]]
[[Category: Tezcan FA]]
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