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[[Image:3tyi.png|left|200px]]


{{STRUCTURE_3tyi| PDB=3tyi | SCENE= }}
==Crystal Structure of Cytochrome c - p-Sulfonatocalix[4]arene Complexes==
<StructureSection load='3tyi' size='340' side='right'caption='[[3tyi]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3tyi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TYI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.399&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=T3Y:25,26,27,28-TETRAHYDROXYPENTACYCLO[19.3.1.1~3,7~.1~9,13~.1~15,19~]OCTACOSA-1(25),3(28),4,6,9(27),10,12,15(26),16,18,21,23-DODECAENE-5,11,17,23-TETRASULFONIC+ACID'>T3Y</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tyi OCA], [https://pdbe.org/3tyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tyi RCSB], [https://www.ebi.ac.uk/pdbsum/3tyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tyi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CYC1_YEAST CYC1_YEAST] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Small molecules that recognize protein surfaces are important tools for modifying protein interaction properties. Since the 1980s, several thousand studies concerning calixarenes and host-guest interactions have been published. Although there is growing interest in protein-calixarene interactions, only limited structural information has been available to date. We now report the crystal structure of a protein-calixarene complex. The water-soluble p-sulfonatocalix[4]arene is shown to bind the lysine-rich cytochrome c at three different sites. Binding curves obtained from NMR titrations reveal an interaction process that involves two or more binding sites. Together, the data indicate a dynamic complex in which the calixarene explores the surface of cytochrome c. In addition to providing valuable information on protein recognition, the data also indicate that the calixarene is a mediator of protein-protein interactions, with potential applications in generating assemblies and promoting crystallization.


===Crystal Structure of Cytochrome c - p-Sulfonatocalix[4]arene Complexes===
Protein camouflage in cytochrome c-calixarene complexes.,McGovern RE, Fernandes H, Khan AR, Power NP, Crowley PB Nat Chem. 2012 Apr 29;4(7):527-33. doi: 10.1038/nchem.1342. PMID:22717436<ref>PMID:22717436</ref>


{{ABSTRACT_PUBMED_22717436}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 3tyi" style="background-color:#fffaf0;"></div>
[[3tyi]] is a 2 chain structure of [[Cytochrome c]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TYI OCA].


==See Also==
==See Also==
*[[Cytochrome c|Cytochrome c]]
*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:022717436</ref><references group="xtra"/>
__TOC__
[[Category: Saccharomyces cerevisiae]]
</StructureSection>
[[Category: Crowley, P B]]
[[Category: Large Structures]]
[[Category: Fernandes, H]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Govern, R EMc.]]
[[Category: Crowley PB]]
[[Category: Khan, A R]]
[[Category: Fernandes H]]
[[Category: All alpha]]
[[Category: Khan AR]]
[[Category: Electron carrier protein]]
[[Category: Mc Govern RE]]
[[Category: Electron transport]]
[[Category: Mitochondrion]]
Retrieved from "https://proteopedia.org/3tyi"