2xfh: Difference between revisions

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==Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.==
==Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.==
<StructureSection load='2xfh' size='340' side='right' caption='[[2xfh]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2xfh' size='340' side='right'caption='[[2xfh]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vrv 2vrv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XFH FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xfh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XFH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL6:1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE'>CL6</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wio|2wio]], [[2jjn|2jjn]], [[2vrv|2vrv]], [[2jjp|2jjp]], [[2jjo|2jjo]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL6:1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE'>CL6</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfh OCA], [http://pdbe.org/2xfh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xfh RCSB], [http://www.ebi.ac.uk/pdbsum/2xfh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xfh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfh OCA], [https://pdbe.org/2xfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xfh RCSB], [https://www.ebi.ac.uk/pdbsum/2xfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xfh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ERYK_SACEN ERYK_SACEN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/2xfh_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/2xfh_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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</div>
</div>
<div class="pdbe-citations 2xfh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2xfh" style="background-color:#fffaf0;"></div>
==See Also==
*[[Cytochrome P450|Cytochrome P450]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Gianni, S]]
[[Category: Large Structures]]
[[Category: Montemiglio, L C]]
[[Category: Saccharopolyspora erythraea]]
[[Category: Savino, C]]
[[Category: Gianni S]]
[[Category: Vallone, B]]
[[Category: Montemiglio LC]]
[[Category: Erythromycin a biosynthesis]]
[[Category: Savino C]]
[[Category: Monoxygenase]]
[[Category: Vallone B]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/2xfh"